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Nature 455, 293-294 (18 September 2008) | doi:10.1038/455293a; Published online 17 September 2008
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Cancer: Hedgehog's other great trick
Tom Curran1 & Jessica M. Y. Ng1
Abstract
The poet Archilochus wrote "The fox has many tricks, and the hedgehog one great one". Yet a signalling-pathway namesake of hedgehog may have two great tricks that could be exploited for cancer therapy.
Molecular signalling pathways that control the growth of cancer cells have been heralded as prime targets for the treatment of a broad spectrum of tumours1. Of particular interest is the hedgehog pathway, which normally is involved in development but whose abnormal activity is thought to drive the proliferation of cancer cells.
- Tom Curran and Jessica M. Y. Ng are at the Joseph Stokes Jr. Research Institute, The Children's Hospital of Philadelphia, 517 Abramson Research Center, Philadelphia, Pennsylvania 19104-4318, USA.
Email: currant@chop.edu; ngj@chop.edu
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RESEARCH
Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract developmentKidney International Original Article
A paracrine requirement for hedgehog signalling in cancerNature Letters to Editor (18 Sep 2008)
