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T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

Marko Pesu, Wendy T. Watford, Lai Wei, Lili Xu, Ivan Fuss, Warren Strober, John Andersson, Ethan M. Shevach, Martha Quezado, Nicolas Bouladoux, Anton Roebroek, Yasmine Belkaid, John Creemers & John J. O'Shea

Nature 455, 246-250(11 September 2008)

doi:10.1038/nature07210

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Figure 1

Normal thymic T-cell development, but activated/memory phenotype of peripheral T cells in CD4cre-furf/f mice.

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Figure 2

Development of age-related autoimmunity in CD4cre-furf/f mice.

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Figure 3

Deletion of furin in T cells results in T-cell expansion/activation, and impairs TGF-beta1 production and CD103 expression.

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Figure 4

Furin deficiency results in increased T effector cell aggressiveness and impaired T regulatory cell protection in suppressing colitis.

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