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Nature 455, 44-45 (4 September 2008) | doi:10.1038/455044a; Published online 3 September 2008
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Small RNAs: The seeds of silence
Zissimos Mourelatos1
Abstract
Individual microRNA sequences can suppress the production of hundreds of proteins. Reduction of protein levels in this way is often modest, however, and many such RNAs probably collectively fine-tune gene expression.
MicroRNAs (miRNAs) are RNA sequences, roughly 23 nucleotides long, that are crucial regulators of gene expression. As part of an RNA–protein complex, these sequences form complementary base pairs with their target messenger RNA sequences, mediating mRNA degradation and/or repressing the translation of the mRNA into protein1, 2.
- Zissimos Mourelatos is in the Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Email: mourelaz@uphs.upenn.edu
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