FIGURE 3. 3D structure of the HIV-1 spike in complex with CD4 and 17b-Fab.
From the following article:
Molecular architecture of native HIV-1 gp120 trimers
Jun Liu, Alberto Bartesaghi, Mario J. Borgnia, Guillermo Sapiro & Sriram Subramaniam
Nature 455, 109-113(4 September 2008)
doi:10.1038/nature07159
a, b, Front and top views showing the X-ray coordinates of the ternary complex (PDB ID, 1GC1) of the gp120 core (red) with CD4 (yellow) and the Fab fragment of 17b (cyan) fitted into the map as a rigid body using automated fitting procedures27. The arrow in a points to the likely location of the V1/V2 loop region, which was partially deleted in the construct used to obtain crystals of the ternary complex2. c–e, Top views showing superposition of the X-ray coordinates for the gp120 trimer derived from the maps for the unliganded (white), b12-bound (cyan) and CD4/17b-bound (yellow) states of the trimeric spike, with locations of the V1/V2 stem regions indicated in red.
Download file
If the slide opens in your browser, select "File > Save As" to save it.
Download Power Point slide (654K)Slides may be downloaded for educational use, according to the terms described in Nature Publishing Group's licensing policy.
BACK TO ARTICLE