Crystal structure of the polymerase PAC|[ndash]|PB1N complex from an avian influenza H5N1 virus

doi:doi:10.1038/nature07120

From the following article:

Crystal structure of the polymerase PA_C–PB1_N complex from an avian influenza H5N1 virus

Xiaojing He, Jie Zhou, Mark Bartlam, Rongguang Zhang, Jianyuan Ma, Zhiyong Lou, Xuemei Li, Jingjing Li, Andrzej Joachimiak, Zonghao Zeng, Ruowen Ge, Zihe Rao & Yingfang Liu

Nature 454, 1123-1126(28 August 2008)

doi:10.1038/nature07120

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The file contains Supplementary Figures and Legends S1-S5; Supplementary Tables T1 and T2.

The Supplementary Figures show a multiple sequence alignment for PAC and PB1N (S1), representative electron density (S2) and known mutation sites for the PAC structure (S3), together with in vitro binding assays for PB1N to several double-point mutants of PAC (S4) and a superposition between structures of PAC and 3 reovirus polymerase N-terminal domain (S5). The Supplementary Table T1 includes data collection, phasing and refinement statistics for PAC:PB1N. The Supplementary Table T2 includes a prediction of the effects of several known mutations in PAC.

The file contains Supplementary Figures and Legends S1-S5; Supplementary Tables T1 and T2. - Download PDF file (670KB)

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