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Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

Subba Rao Gangi Setty, Danièle Tenza, Elena V. Sviderskaya, Dorothy C. Bennett, Graça Raposo & Michael S. Marks

Nature 454, 1142-1146(28 August 2008)

doi:10.1038/nature07163

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Figure 1

Copper transporter ATP7A localizes to melanosomes in wild-type melanocytes.

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Figure 2

ATP7A is mislocalized to early endosomes in BLOC-1-deficient melanocytes.

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Figure 3

Tyrosinase is present but inactive in BLOC-1-deficient melanocytes.

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Figure 4

Copper restores in vitro tyrosinase activity in melanosomes of BLOC-1-deficient melanocytes.

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