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UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

Zane B. Andrews, Zhong-Wu Liu, Nicholas Walllingford, Derek M. Erion, Erzsebet Borok, Jeffery M. Friedman, Matthias H. Tschöp, Marya Shanabrough, Gary Cline, Gerald I. Shulman, Anna Coppola, Xiao-Bing Gao, Tamas L. Horvath & Sabrina Diano

Nature 454, 846-851(14 August 2008)

doi:10.1038/nature07181

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Figure 1

Mitochondrial and transcriptional effects of ghrelin are mediated by UCP2.

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Figure 2

Effects of ghrelin on neuronal firing, synaptic plasticity and feeding are mediated by UCP2.

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Figure 3

Ghrelin activates an intracellular pathway of fatty acid metabolism.

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Figure 4

ROS is a critical regulator of cellular and behavioural responses to ghrelin.

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