Table of contents
Volume 454 Number 7205 pp667-804
(this content only available online) indicates content that is available online only
Editorials
A level playing field? p667
Drug testing in sport aims to promote fair play, but the science behind the tests needs to be more open.
doi:10.1038/454667a
Clean hands, please p667
The Italian government needs to maintain a careful distance from industry.
doi:10.1038/454667b
Research Highlights
Ecology: Turf wars p670
doi:10.1038/454670a
Astrophysics: First light p670
doi:10.1038/454670b
Ecology: Fungus hunters p670
doi:10.1038/454670c
Animal behaviour: Is he into her? p670
doi:10.1038/454670d
Palaeoclimate: Quick start to a cold spell p670
doi:10.1038/454670e
Molecular biology: Going farther p670
doi:10.1038/454670f
Animal behaviour: Love song p671
doi:10.1038/454671a
Cell biology: Starve and reproduce p671
doi:10.1038/454671b
Neurobiology: Baby blues p671
doi:10.1038/454671c
Geology: The end of flat Earth p671
doi:10.1038/454671d
News
Death renews biosecurity debate p672
Microbiologist's suicide over anthrax case raises questions on US regulations.
Amber Dance
doi:10.1038/454672a
Climate war games p673
Role-play negotiations test the outcomes of global warming.
Jeff Tollefson
doi:10.1038/454673a
Genetic fact-check for ageing story p674
Study probes geriatric gene pool.
Meredith Wadman
doi:10.1038/454674a
Full Text
| PDF (300k)
See also: Editor's summary
Snapshot: Earth rocks p675
Katrina Charles
doi:10.1038/454675a
Nerve cells made from elderly patient's skin cells p675
Reprogrammed cells may offer insight into neurodegenerative disease.
Monya Baker
doi:10.1038/454675b
'Virophage' suggests viruses are alive p677
Evidence of illness enhances case for life.
Helen Pearson
doi:10.1038/454677a
Lawsuit chips away at fish research p678
Court order may halt attempts to train sea bass.
Amber Dance
doi:10.1038/454678a
Stanford psychiatrist removed from drug study p679
doi:10.1038/454679a
Third failure for private rocket launch p679
doi:10.1038/454679b
Canadian observatory sold to property developer p679
doi:10.1038/454679c
Researcher wins claim for accidental infection p679
doi:10.1038/454679d
Germany tinkers with university regulations p679
doi:10.1038/454679e
Rock art carves itself a niche online p679
doi:10.1038/454679f
Column
Party of OneFinancial planning p680
An impasse over the budget and the impending presidential election mean that US science spending will likely be frozen for months, David Goldston reports.
David Goldston
doi:10.1038/454680a
News Features
Neuroscience: Standard model p682
Questions raised about the use of 'ALS mice' are prompting a broad reappraisal of the way that drugs are tested in animal models of neurodegenerative disease. Jim Schnabel reports.
doi:10.1038/454682a
Full Text
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See also: Editor's summary
Interdisciplinary science: Harvard under review p686
Harvard is embarking on an experiment to foster collaboration and interdisciplinary research. Corie Lok looks at whether it can change its culture and reinvent communities along the way.
doi:10.1038/454686a
Correspondence
Small countries are unexpected winners in ERC grant tables p690
Friedrich Frischknecht
doi:10.1038/454690a
Human microbiome: hype or false modesty? p690
David R. Whitlock
doi:10.1038/454690b
Human microbiome: take-home lesson on growth promoters? p690
Didier Raoult
doi:10.1038/454690c
Some alphabets easily beat Russian letter count p691
Mikhail S. Gelfand
doi:10.1038/454691a
Medical Research Council values basic research p691
Leszek Borysiewicz
doi:10.1038/454691b
Why does work on same mouse models give different results? p691
Padraic G. Fallon
doi:10.1038/454691c
Commentary
The science of doping p692
The processes used to charge athletes with cheating are often based on flawed statistics and flawed logic, says Donald A. Berry.
doi:10.1038/454692a
Books and Arts
Powers of observation p694
A perceptive history documents the many remarkable people who envisioned, built and launched the Hubble Space Telescope, explains Robert A. Brown.
Robert A. Brown reviews The Universe in a Mirror: The Saga of the Hubble Space Telescope and the Visionaries Who Built It by Robert Zimmerman
doi:10.1038/454694a
Living Googles? p695
Simon Baron-Cohen reviews Representing Autism: Culture, Narrative, Fascination by Stuart Murray
doi:10.1038/454695a
Culture dish p696
doi:10.1038/454696a
Visions of our far future p696
Jon Turney reviews Year Million: Science at the Far Edge of Knowledge
doi:10.1038/454696b
Q&A: Turning up the heat on sci-fi p698
The novel Hothouse is Brian Aldiss's extraordinary 1962 vision of rampant global warming, set on a future stationary Earth with one side permanently baked by the Sun. As the book is republished as a Penguin Modern Classic, the 83-year-old author shares his thoughts on science fiction and life with Nature.
Caspar Henderson reviews Hothouse by Brian Aldiss
doi:10.1038/454698a
Hidden treasures: Padua's anatomy theatre p699
Alison Abbott finds that human dissections during the Renaissance were rather respectable after all.
Alison Abbott
doi:10.1038/454699a
News and Views
Earth science: Structuring the inner core p701
Earth's rocky mantle and solid inner core are separated by the 2,300-kilometre-deep layer of molten iron that constitutes the outer core. Yet the sluggish pattern of mantle convection creates structure in the inner core.
John Lister
doi:10.1038/454701a
See also: Editor's summary
Tuberculosis: Shrewd survival strategy p702
Mycobacterium tuberculosis modulates its virulence to cause persistent but often subclinical infection. This strategy is regulated in part by a feedback loop that controls the secretion of a small subset of bacterial proteins.
Steven A. Porcelli
doi:10.1038/454702a
See also: Editor's summary
Optics: Electronic eyeballs p703
The ability to fabricate silicon optoelectronic devices on a curved surface will lead to imaging systems with exceptional characteristics. This innovative technology will find diverse applications.
Takao Someya
doi:10.1038/454703a
See also: Editor's summary
Pharmacology: Unready for action p704
Boy scouts recognize that the key to success is to be prepared. The same is true of molecules that bind to and open ion channels — the least effective ones are slower to prepare the channel to be ready for opening.
Joe Henry Steinbach
doi:10.1038/454704a
See also: Editor's summary
Materials science: Protein gels on the move p705
Light-induced reactions enable three-dimensional objects to be built from simple compounds. Proteins have been added to the list of building blocks, and the resulting gels move in response to environmental cues.
April M. Kloxin & Kristi S. Anseth
doi:10.1038/454705a
Alzheimer's disease: The latest suspect p706
Many genetic mutations and several environmental factors contribute to Alzheimer's disease. Yet another disease risk gene, one that is involved in calcium regulation, has been added to the mix.
Rudolph E. Tanzi & Lars Bertram
doi:10.1038/454706a
50 & 100 Years Ago p707
doi:10.1038/454707a
Nanotechnology: Diamonds are for tethers p708
Modified diamond nanowires produce an electrical response on binding to DNA. This gem of a discovery could pave the way to robust biosensors that use electrical signals to detect molecules.
Robert J. Hamers
doi:10.1038/454708a
Cell biology: A molecular age barrier p709
A mother's instinct is to protect her children at any cost. In the budding yeast Saccharomyces cerevisiae this 'maternal instinct' comes at a high price — accelerated ageing and premature death.
Matt Kaeberlein
doi:10.1038/454709a
See also: Editor's summary
Palaeontology: Bite size p710
Tim Lincoln
doi:10.1038/454710a
Feature
Moving AHEAD with an international human epigenome project p711
A plan to 'genomicize' epigenomics research and pave the way for breakthroughs in the prevention, diagnosis and treatment of human disease.
The American Association for Cancer Research Human Epigenome Task Force & European Union, Network of Excellence, Scientific Advisory Board
doi:10.1038/454711a
Articles
Secreted transcription factor controls Mycobacterium tuberculosis virulence p717
Sridharan Raghavan, Paolo Manzanillo, Kaman Chan, Cole Dovey & Jeffery S. Cox
doi:10.1038/nature07219
Abstract | Full Text | PDF (699K) | Supplementary information
See also: Editor's summary
On the nature of partial agonism in the nicotinic receptor superfamily p722
Remigijus Lape, David Colquhoun & Lucia G. Sivilotti
doi:10.1038/nature07139
Abstract | Full Text | PDF (752K) | Supplementary information
See also: Editor's summary
A mechanism for asymmetric segregation of age during yeast budding p728
Zhanna Shcheprova, Sandro Baldi, Stephanie Buvelot Frei, Gaston Gonnet & Yves Barral
doi:10.1038/nature07212
Abstract | Full Text | PDF (1,406K) | Supplementary information
See also: Editor's summary
Letters
Clumps and streams in the local dark matter distribution p735
J. Diemand, M. Kuhlen, P. Madau, M. Zemp, B. Moore, D. Potter & J. Stadel
doi:10.1038/nature07153
First paragraph | Full Text | PDF (464K) | Supplementary information
See also: Editor's summary
Determination of the fermion pair size in a resonantly interacting superfluid p739
Christian H. Schunck, Yong-il Shin, André Schirotzek & Wolfgang Ketterle
doi:10.1038/nature07176
First paragraph | Full Text | PDF (372K) | Supplementary information
See also: Editor's summary
Using photoemission spectroscopy to probe a strongly interacting Fermi gas p744
J. T. Stewart, J. P. Gaebler & D. S. Jin
doi:10.1038/nature07172
First paragraph | Full Text | PDF (415K)
See also: Editor's summary
A hemispherical electronic eye camera based on compressible silicon optoelectronics p748
Heung Cho Ko, Mark P. Stoykovich, Jizhou Song, Viktor Malyarchuk, Won Mook Choi, Chang-Jae Yu, Joseph B. Geddes III, Jianliang Xiao, Shuodao Wang, Yonggang Huang & John A. Rogers
doi:10.1038/nature07113
First paragraph | Full Text | PDF (1,035K) | Supplementary information
See also: Editor's summary
Rapid change in drift of the Australian plate records collision with Ontong Java plateau p754
Kurt M. Knesel, Benjamin E. Cohen, Paulo M. Vasconcelos & David S. Thiede
doi:10.1038/nature07138
First paragraph | Full Text | PDF (1,948K) | Supplementary information
See also: Editor's summary
Thermochemical flows couple the Earth's inner core growth to mantle heterogeneity p758
Julien Aubert, Hagay Amit, Gauthier Hulot & Peter Olson
doi:10.1038/nature07109
First paragraph | Full Text | PDF (1,425K) | Supplementary information
See also: Editor's summary
Escape from adaptive conflict after duplication in an anthocyanin pathway gene p762
David L. Des Marais & Mark D. Rausher
doi:10.1038/nature07092
First paragraph | Full Text | PDF (236K) | Supplementary information
Genome-scale DNA methylation maps of pluripotent and differentiated cells p766
Alexander Meissner, Tarjei S. Mikkelsen, Hongcang Gu, Marius Wernig, Jacob Hanna, Andrey Sivachenko, Xiaolan Zhang, Bradley E. Bernstein, Chad Nusbaum, David B. Jaffe, Andreas Gnirke, Rudolf Jaenisch & Eric S. Lander
doi:10.1038/nature07107
First paragraph | Full Text | PDF (3,135K) | Supplementary information
See also: Editor's summary
cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila p771
Sung-Tae Hong, Sunhoe Bang, Seogang Hyun, Jongkyun Kang, Kyunghwa Jeong, Donggi Paik, Jongkyeong Chung & Jaeseob Kim
doi:10.1038/nature07090
First paragraph | Full Text | PDF (403K) | Supplementary information
See also: Editor's summary
Essential roles of PI(3)K–p110
in cell growth, metabolism and tumorigenesis p776
Shidong Jia, Zhenning Liu, Sen Zhang, Pixu Liu, Lei Zhang, Sang Hyun Lee, Jing Zhang, Sabina Signoretti, Massimo Loda, Thomas M. Roberts & Jean J. Zhao
doi:10.1038/nature07091
First paragraph | Full Text | PDF (478K) | Supplementary information
See also: Editor's summary
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs p780
Jennifer Lin Umbach, Martha F. Kramer, Igor Jurak, Heather W. Karnowski, Donald M. Coen & Bryan R. Cullen
doi:10.1038/nature07103
First paragraph | Full Text | PDF (452K) | Supplementary information
See also: Editor's summary
Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans p784
Michael E. Llewellyn, Robert P. J. Barretto, Scott L. Delp & Mark J. Schnitzer
doi:10.1038/nature07104
First paragraph | Full Text | PDF (963K) | Supplementary information
See also: Editor's summary
Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex p789
Yong Gong, Peng Cao, Hong-jun Yu & Tao Jiang
doi:10.1038/nature07089
PDB code
3D view
First paragraph | Full Text | PDF (791K) | Supplementary information
See also: Editor's summary
Corrigendum
Dissecting direct reprogramming through integrative genomic analysis p794
Tarjei S. Mikkelsen, Jacob Hanna, Xiaolan Zhang, Manching Ku, Marius Wernig, Patrick Schorderet, Bradley E. Bernstein, Rudolf Jaenisch, Eric S. Lander & Alexander Meissner
doi:10.1038/nature07196
Technology Features
Epigenomics: Detailed analysis p795
Researchers now have access to a burgeoning collection of tools for unravelling the epigenome, which could lead to new drug targets and ways to track disease. Laura Bonetta reports.
doi:10.1038/454795a
See also: Editor's summary
Epigenomics: Tackling the epigenome p795
doi:10.1038/454795b
Epigenomics: Tools of the trade p796
doi:10.1038/454796a
Epigenomics: Table of suppliers p799
doi:10.1038/454799a
Naturejobs
ProspectProspects p801
Statistical analyses raise questions over NIH grant reviews.
Gene Russo
doi:10.1038/nj7205-801a
