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Nature 454, 795-798 (7 August 2008) | doi:10.1038/454795a; Published online 6 August 2008
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Epigenomics: Detailed analysis
Laura Bonetta1
Abstract
Researchers now have access to a burgeoning collection of tools for unravelling the epigenome, which could lead to new drug targets and ways to track disease. Laura Bonetta reports.
Just as DNA mutations can cause disease, so too can changes in gene activity that don't depend on DNA sequence. For example, the addition of methyl groups to cytosines within the promoter regions of a gene, a process known as DNA methylation, typically represses the gene's activity.
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NEWS AND VIEWS
Toward a human epigenomeNature Genetics News and Views (01 Dec 2006)
Locking in on the human methylomeNature Biotechnology News and Views (01 Apr 2009)
