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Nature 454, 706-708 (7 August 2008) | doi:10.1038/454706a; Published online 6 August 2008
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Alzheimer's disease: The latest suspect
Rudolph E. Tanzi1 & Lars Bertram1
Abstract
Many genetic mutations and several environmental factors contribute to Alzheimer's disease. Yet another disease risk gene, one that is involved in calcium regulation, has been added to the mix.
Alzheimer's disease is characterized by neurodegeneration in several brain areas, with the hippocampus being one of the first regions affected. Accumulation of aggregates of the amyloid-
peptide, for example in the form of senile plaques, is another feature of this disorder.
- Rudolph E. Tanzi and Lars Bertram are in the Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease (MIND), Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
Email: tanzi@helix.mgh.harvard.edu
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