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Editorials

A chorus of disapproval p551

The fight against AIDS is losing ground, but the current spate of mud-slinging is far from helpful.

doi:10.1038/454551a


The greener grid p551

Governments need to back an overhaul to get the electricity grid ready for renewable energy.

doi:10.1038/454551b


Europe's science forum p552

Although the Euroscience Open Forum is a meeting to be proud of, its organizers should aim even higher.

doi:10.1038/454552a


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Research Highlights

Planetary physics: Storm warning p554

doi:10.1038/454554a


Molecular biology: Telling time p554

doi:10.1038/454554b


Environmental sciences: Fresh data p554

doi:10.1038/454554c


Physical chemistry: Over ice p554

doi:10.1038/454554d


Nanotechnology: Weighing options p554

doi:10.1038/454554e


Quantum computing: Cloudy computing p554

doi:10.1038/454554f


Molecular biology: Senior signals p555

doi:10.1038/454555a


Photonics: Telescopic TV p555

doi:10.1038/454555b


Immunology: Green vaccines p555

doi:10.1038/454555c


Zoology: Bigmouth strikes again p555

doi:10.1038/454555d


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Journal Club

Journal club p555

Robin Rogers

doi:10.1038/454555e


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News

Consent issues restrict stem-cell use p556

Some human embryonic cell lines may not be eligible for research.

Monya Baker

doi:10.1038/454556a


Italy picks businessman to head space agency p557

Move seen as shift from research to commerce and defence.Geoff Brumfiel

doi:10.1038/454557a


School chemistry off-limits to terrorism suspect p557

UK judge blocks access to high-school-level courses.

Geoff Brumfiel

doi:10.1038/454557b


Thin films: ready for their close-up? p558

New types of solar cell that can be mass-produced cheaply, and integrated into building materials, are popular with venture capitalists and market analysts. But scientists are less gung ho, reports Declan Butler.

Declan Butler

doi:10.1038/454558a


Complex clock combines calendars p561

Antikythera Mechanism may have timetabled ancient Olympic Games.

Philip Ball

doi:10.1038/454561a


Sidelines p562

Scribbles on the margins of science.

doi:10.1038/454562a


Thousands of proteins affected by miRNAs p562

Far from being junk, these snippets of the genome exert wide-ranging influence.

doi:10.1038/454562b


Snapshot: The hidden van Gogh p563

X-ray reveals mystery portrait.

doi:10.1038/454563a


Pier Oddone p563

The director of Fermi National Accelerator Laboratory in Batavia, Illinois, talks to Eric Hand about the uncertain future of particle colliders in the United States.

Eric Hand

doi:10.1038/454563b


Italy launches clinical trial for HIV vaccine p564

doi:10.1038/454564a


Nations pool resources to study lunar seismic activity p564

doi:10.1038/454564b


GlaxoSmithKline cements interest in stem cells p564

doi:10.1038/454564c


Statistics show hint of bias in NIH grant reviews p564

doi:10.1038/454564d


Bail for entomologists held for illegal insect collection p564

doi:10.1038/454564e


Voyage to the bottom of the world's deepest lake p564

doi:10.1038/454564f


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News Features

HIV: The next shot p565

Researchers trying to develop an HIV vaccine have endured two decades of setbacks. Erika Check Hayden meets a veteran still engaged in the fight — and a rookie willing to join in anyway.

doi:10.1038/454565a


Energy: Upgrading the grid p570

Electricity grids must cope with rising demand and complexity in a changing world. Emma Marris explores the intricacies involved in controlling the power supply.

doi:10.1038/454570a


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Correspondence

Integrity: Croatia's standards unusual in much of Europe p574

Xavier Bosch

doi:10.1038/454574a


Integrity: juniors see leaders gain from calculated dishonesty p574

Ned Feder & Walter W. Stewart

doi:10.1038/454574b


Integrity: misconduct by a few damages credibility for many p574

Paulo A. Nussenzveig & Renata Zukanovich Funchal

doi:10.1038/454574c


Integrity: how to measure breaches effectively p575

Judith P. Swazey

doi:10.1038/454575a


Titus et al. reply: p575

Sandra L. Titus, James A. Wells & Lawrence J. Rhoades

doi:10.1038/454575b


Digital identifiers could keep up with authors' moves p575

Raf Aerts

doi:10.1038/454575c


Schools in a third of Spain teach only in minority languages p575

Jose M. Rojo

doi:10.1038/454575d


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Books and Arts

Grand tour with a geologist guide p576

A field guide to the formation of Italy's Apennine mountains mixes the science behind the dinosaur extinction with accounts of travel and Italian history, explains Ted Nield.

Ted Nield reviews The Mountains of St Francis: Discovering the Geologic Events That Shaped Our Earth by Walter Alvarez

doi:10.1038/454576a

See also: Editor's summary


New in Paperback p576

doi:10.1038/454576b


Stalin's war on genetic science p577

Jan Witkowski reviews The Murder of Nikolai Vavilov: The Story of Stalin's Persecution of One of the Great Scientists of the Twentieth Century by Peter Pringle

doi:10.1038/454577a


Betting on black holes p579

Paul Davies reviews The Black Hole War: My Battle with Stephen Hawking to Make the World Safe for Quantum Mechanics by Leonard Susskind

doi:10.1038/454579a


Maths and mad hatters p580

Jascha Hoffman reviews Lewis Carroll in Numberland: His Fantastical Mathematical Logical Life by Robin Wilson

doi:10.1038/454580a


The creationist controversy p581

PZ Myers reviews Only a Theory: Evolution and the Battle for America's Soul by Kenneth R. Miller

doi:10.1038/454581a


Fictional quantum conspiracy p582

Jennifer Rohn reviews Final Theory: A Novel by Mark Alpert

doi:10.1038/454582a


Inside the mind of a marathon runner p583

Andy Miah reviews What I Talk About When I Talk About Running by Haruki Murakami.

doi:10.1038/454583a


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News and Views

Nanotechnology: Patterns from molecular corrals p585

Many nanotechnology devices will require components that consist of arrays of molecules positioned on surfaces with nanometre precision. One way to make these is to let the molecules organize themselves.

Michael Grunze

doi:10.1038/454585a

See also: Editor's summary


Cancer: Ins and outs of tumour control p586

When a potentially dangerous cell can't be repaired, it must be either stopped or killed. Premature senescence of cancerous cells is one such 'stop' mechanism, in which immune mediators play an unexpected part.

Maria S. Soengas

doi:10.1038/454586a


Planetary science: Organic lakes on Titan p587

While orbiting Saturn, the Cassini spacecraft has spotted lakes containing ethane on Titan, the planet's largest moon. Titan is so far the only planetary object other than Earth that is known to have liquid bodies on its surface.

François Raulin

doi:10.1038/454587a


Behavioural neuroscience: The circuit of fear p589

Do you find it difficult to overcome an irrational fear? Blame it on the specific neural circuits hardwired in the brain that control fear recognition, and fear renewal even when fear has seemingly been overcome.

Pankaj Sah & R. Frederick Westbrook

doi:10.1038/454589a

See also: Editor's summary


Materials science: A desirable wind up p591

Multiferroic materials have complex domain structures that make precise interpretation of their behaviours difficult. The creation and study of a single-domain multiferroic crystal is thus an exciting development.

Neil Mathur

doi:10.1038/454591a


Developmental biology: Our fly cousins' gut p592

What do we humans have in common with flies? Quite a lot, at least at the cellular and molecular levels. Our intestine, for instance, is similar to that of the fly, not only in function but also in its development and maintenance.

Chrysoula Pitsouli & Norbert Perrimon

doi:10.1038/454592a

See also: Editor's summary


Structural biology: It's not all in the family p593

There are no sequential snapshots of a transporter protein as it mediates the simultaneous passage of ions and solutes into a cell. Comparing different snapshots of structurally related transporters offers fascinating insights.

Baruch I. Kanner

doi:10.1038/454593a


50 & 100 Years Ago p594

doi:10.1038/454594a


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Brief Communications Arising

Does Rft1 flip an N-glycan lipid precursor? pE3

Christian G. Frank, Sumana Sanyal, Jeffrey S. Rush, Charles J. Waechter & Anant K. Menon

doi:10.1038/nature07165


Helenius et al. reply pE4

Jonne Helenius, Davis T. W. Ng, Cristina L. Marolda, Peter Walter, Miguel A. Valvano & Markus Aebi

doi:10.1038/nature07164



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Articles

A new class of homoserine lactone quorum-sensing signals p595

Amy L. Schaefer, E. P. Greenberg, Colin M. Oliver, Yasuhiro Oda, Jean J. Huang, Gili Bittan-Banin, Caroline M. Peres, Silke Schmidt, Katarina Juhaszova, Janice R. Sufrin & Caroline S. Harwood

doi:10.1038/nature07088

See also: Editor's summary


Switching on and off fear by distinct neuronal circuits p600

Cyril Herry, Stephane Ciocchi, Verena Senn, Lynda Demmou, Christian Müller & Andreas Lüthi

doi:10.1038/nature07166

See also: Editor's summary | News and Views by Sah & Westbrook


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Letters

The identification of liquid ethane in Titan's Ontario Lacus p607

R. H. Brown, L. A. Soderblom, J. M. Soderblom, R. N. Clark, R. Jaumann, J. W. Barnes, C. Sotin, B. Buratti, K. H. Baines & P. D. Nicholson

doi:10.1038/nature07100

See also: Editor's summary | News and Views by Raulin


Scaling the Kondo lattice p611

Yi-feng Yang, Zachary Fisk, Han-Oh Lee, J. D. Thompson & David Pines

doi:10.1038/nature07157

See also: Editor's summary


Calendars with Olympiad display and eclipse prediction on the Antikythera Mechanism p614

Tony Freeth, Alexander Jones, John M. Steele & Yanis Bitsakis

doi:10.1038/nature07130

See also: Editor's summary


Functionalizing hydrogen-bonded surface networks with self-assembled monolayers p618

Rafael Madueno, Minna T. Räisänen, Christophe Silien & Manfred Buck

doi:10.1038/nature07096

See also: Editor's summary


Primary carbonatite melt from deeply subducted oceanic crust p622

M. J. Walter, G. P. Bulanova, L. S. Armstrong, S. Keshav, J. D. Blundy, G. Gudfinnsson, O. T. Lord, A. R. Lennie, S. M. Clark, C. B. Smith & L. Gobbo

doi:10.1038/nature07132

See also: Editor's summary


Environmental determinants of extinction selectivity in the fossil record p626

Shanan E. Peters

doi:10.1038/nature07032

See also: Editor's summary


Evolutionary origin and development of snake fangs p630

Freek J. Vonk, Jeroen F. Admiraal, Kate Jackson, Ram Reshef, Merijn A. G. de Bakker, Kim Vanderschoot, Iris van den Berge, Marit van Atten, Erik Burgerhout, Andrew Beck, Peter J. Mirtschin, Elazar Kochva, Frans Witte, Bryan G. Fry, Anthony E. Woods & Michael K. Richardson

doi:10.1038/nature07178

See also: Editor's summary


The abundance threshold for plague as a critical percolation phenomenon p634

S. Davis, P. Trapman, H. Leirs, M. Begon & J. A. P. Heesterbeek

doi:10.1038/nature07053

See also: Editor's summary


An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth p638

Jamie M. Verheyden & Xin Sun

doi:10.1038/nature07085

See also: Editor's summary


Amygdala intercalated neurons are required for expression of fear extinction p642

Ekaterina Likhtik, Daniela Popa, John Apergis-Schoute, George A. Fidacaro & Denis Paré

doi:10.1038/nature07167

See also: Editor's summary | News and Views by Sah & Westbrook


Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors p646

Jeong Beom Kim, Holm Zaehres, Guangming Wu, Luca Gentile, Kinarm Ko, Vittorio Sebastiano, Marcos J. Araúzo-Bravo, David Ruau, Dong Wook Han, Martin Zenke & Hans R. Schöler

doi:10.1038/nature07061

See also: Editor's summary


The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling p651

Shigeo Takashima, Marianna Mkrtchyan, Amelia Younossi-Hartenstein, John R. Merriam & Volker Hartenstein

doi:10.1038/nature07156

See also: Editor's summary | News and Views by Pitsouli & Perrimon


Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation p656

Tuomas Tammela, Georgia Zarkada, Elisabet Wallgard, Aino Murtomäki, Steven Suchting, Maria Wirzenius, Marika Waltari, Mats Hellström, Tibor Schomber, Reetta Peltonen, Catarina Freitas, Antonio Duarte, Helena Isoniemi, Pirjo Laakkonen, Gerhard Christofori, Seppo Ylä-Herttuala, Masabumi Shibuya, Bronislaw Pytowski, Anne Eichmann, Christer Betsholtz & Kari Alitalo

doi:10.1038/nature07083

See also: Editor's summary


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Naturejobs

Prospect

Prospects p661

The issues of translation and tough choices in science careers.

Gene Russo

doi:10.1038/nj7204-661a


Careers and Recruitment

Political will p662

Scientists who enter the world of political advocacy stand to gain perspective but could face a culture shock. Gene Russo reports.

Gene Russo

doi:10.1038/nj7204-662a


Career View

Joyce DeLeo, chair, Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire p664

Neuroanatomist takes multidisciplinary approach at Dartmouth.

Virginia Gewin

doi:10.1038/nj7204-664a


The gender imbalance p664

NIH announces grants for investigating gender disparity.

Paul Smaglik

doi:10.1038/nj7204-664b


'Force'-full wisdom p664

New animal model, new challenges

Amanda Goh

doi:10.1038/nj7204-664c


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Futures

The pair-bond imperative p666

What's love got to do with it?

Jennifer Rohn

doi:10.1038/454666a


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