Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 454, 592-593 (31 July 2008) | doi:10.1038/454592a; Published online 30 July 2008
Open Innovation Challenges
-
Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
-
Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
- More Challenges
- Powered by:
nature jobs
Canada Excellence Research Chair in Quantum Materials and Devices Based on Oxide Heterostructures
- University of British Columbia
- Vancouver, British Columbia Canada
Professorship in Agricultural Engineering
- University of Natural Resources and Applied Life Sciences Vienna
- Vienna, Austria
Developmental biology: Our fly cousins' gut
Chrysoula Pitsouli1 & Norbert Perrimon1
Abstract
What do we humans have in common with flies? Quite a lot, at least at the cellular and molecular levels. Our intestine, for instance, is similar to that of the fly, not only in function but also in its development and maintenance.
Epithelial cells lining the intestine become damaged by ingested food, pathogens and toxins, and so must be constantly renewed. Intestinal stem cells compensate for the loss of these cells by producing all of the mature intestinal epithelial cell types1, and an imbalance in this process can lead to diseases such as cancer2.
- Chrysoula Pitsouli and Norbert Perrimon are in the Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Email: perrimon@receptor.med.harvard.edu
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signallingNature Letters to Editor (31 Jul 2008)
Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cellsNature Letters to Editor (23 Oct 2008)
The adult Drosophila posterior midgut is maintained by pluripotent stem cellsNature Letters to Editor (26 Jan 2006)
See all 4 matches for Research