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Nature 454, 463-469 (24 July 2008) | doi:10.1038/nature07206; Published online 23 July 2008
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Laboratory Technician (Pharmaceutics)
- Alliance Institute of Advanced Pharmacy and Health Sciences
- Hyderabad 500038 India
One Postdoctoral Position at Centre for Research in Agricultural Genomics
- The Centre for Research Agricultural Genomics Consorcio CSIC-IRTA-UAB
- Barcelona Spain
Hypothesis Article The role of exercise and PGC1
in inflammation and chronic disease
Christoph Handschin1 & Bruce M. Spiegelman2
Abstract
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1
has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
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