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Insight
Nature 454, 455-462 (24 July 2008) | doi:10.1038/nature07203; Published online 23 July 2008
Open Innovation Challenges
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Senior Scientific Programmer (Macromolecular Crystallography)
- European Bioinformatics Institute (EBI)
- Cambridge CB10 1SD United Kingdom
Two New Permanent Positions - Genomics, Epigenomics or Systems Biology
- Centro de Biotecnologia y Genomica de Plantas
- Madrid Spain
Review Article From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang1,2 & Randal J. Kaufman1,3,4
Abstract
The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.
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