Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 454, 455-462 (24 July 2008) | doi:10.1038/nature07203; Published online 23 July 2008
Open Innovation Challenges
-
Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Section Chief of Molecular Diagnostics and Medical Director of Molecular Diagnotics Laboratory
- M. D. Anderson Cancer Center
- Houston, Texas, USA
Chemical Process Engineer
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Review Article From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang1,2 & Randal J. Kaufman1,3,4
Abstract
The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Presenilin mutants subvert chaperone functionNature Cell Biology News and Views (01 Feb 2000)
Unfolding the toxicity of cholesterolNature Cell Biology News and Views (01 Sep 2003)
The stressful road to antibody secretionNature Immunology News and Views (01 Apr 2003)
