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Nature 454, 470-477 (24 July 2008) | doi:10.1038/nature07202; Published online 23 July 2008
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Organic Chemistry
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Executive- Commercial- Corporate Office
- Rhydburg Pharmaceuticals
- Selaqui-Dehradun India
Review Article Integration of metabolism and inflammation by lipid-activated nuclear receptors
Steven J. Bensinger1 & Peter Tontonoz1
Abstract
The nuclear receptors known as PPARs and LXRs are lipid-activated transcription factors that have emerged as key regulators of lipid metabolism and inflammation. PPARs and LXRs are activated by non-esterified fatty acids and cholesterol metabolites, respectively, and both exert positive and negative control over the expression of a range of metabolic and inflammatory genes. The ability of these nuclear receptors to integrate metabolic and inflammatory signalling makes them attractive targets for intervention in human metabolic diseases, such as atherosclerosis and type 2 diabetes, as well as for the modulation of inflammation and immune responses.
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