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Nature 454, 421-422 (24 July 2008) | doi:10.1038/454421a; Published online 23 July 2008
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Senior Scientific Manager / Chief Scientific Manager for Metabolic Disorder and Cardiavascular Area In Vivo Pharmacology / Biology
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Postdoctoral Associate in Enzyme Biochemistry
- Cornell University
- Ithaca, New York
Genomics: Thoroughly modern meiosis
Michael Lichten1
Abstract
Meiotic recombination shuffles the genome, so each generation inherits a new combination of parental traits. Combining traditional and modern approaches, new work pinpoints where recombination occurs genome-wide.
During meiosis, a diploid cell (with two copies of each chromosome, one from each parent) undergoes two rounds of cell division, producing haploid gametes — in animals, these are sperm or eggs containing a single copy of each chromosome. Genetic recombination, which occurs at high levels during meiotic cell division, is crucial for chromosome separation in the diploid-to-haploid transition, and mixes parental genomic sequences to generate genetic diversity in the next generation.
- Michael Lichten is in the Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4260, USA.
Email: lichten@helix.nih.gov
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