Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 454, 421-422 (24 July 2008) | doi:10.1038/454421a; Published online 23 July 2008
nature jobs
Publisher, Academic Journals (USA)
- Nature Publishing Group
- New York, NY
Postdoctoral Position (CNS Biomarkers)
- F. Hoffmann-La Roche AG
- Basel 4000 Switzerland
Genomics: Thoroughly modern meiosis
Michael Lichten1
Abstract
Meiotic recombination shuffles the genome, so each generation inherits a new combination of parental traits. Combining traditional and modern approaches, new work pinpoints where recombination occurs genome-wide.
During meiosis, a diploid cell (with two copies of each chromosome, one from each parent) undergoes two rounds of cell division, producing haploid gametes — in animals, these are sperm or eggs containing a single copy of each chromosome. Genetic recombination, which occurs at high levels during meiotic cell division, is crucial for chromosome separation in the diploid-to-haploid transition, and mixes parental genomic sequences to generate genetic diversity in the next generation.
- Michael Lichten is in the Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4260, USA.
Email: lichten@helix.nih.gov
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
High-resolution mapping of meiotic crossovers and non-crossovers in yeastNature Article (24 Jul 2008)
Distribution of the Rad51 recombinase in human and mouse spermatocytesThe EMBO Journal Article (01 Sep 1997)
