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Nature 454, 416-417 (24 July 2008) | doi:10.1038/454416a; Published online 23 July 2008
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Physiology: Myoglobin's new clothes
Andrew Cossins1 & Michael Berenbrink1
Abstract
Nitric oxide generated from the nitrite ion limits the tissue damage caused by restricted blood flow. Gene knockout experiments in mice now reveal that myoglobin is the mediator of this effect.
All students of biology encounter the richly pigmented protein myoglobin early in their education, where it provides the first and most famous example of a revealed protein structure combined with a straightforward physiological role. Its restricted distribution to endurance muscle and heart cells throughout the vertebrates, and its notable expression in diving mammals, are a reflection of its widely accepted function in cellular oxygen transport and oxygen buffering.
- Andrew Cossins and Michael Berenbrink are in the School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK.
Email: cossins@liverpool.ac.uk
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