FIGURE 3. Inactivity and obesity as risk factors for developing chronic diseases.

From the following article:

The role of exercise and PGC1alpha in inflammation and chronic disease

Christoph Handschin & Bruce M. Spiegelman

Nature 454, 463-469(24 July 2008)

doi:10.1038/nature07206

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How lifestyle affects the age of onset of chronic diseases and the incidence of these diseases is depicted, using theoretical estimates. The baseline is individuals who engage in the recommended amount of physical activity (yellow). A sedentary lifestyle (green) lowers the threshold for the age of onset and the incidence of chronic diseases (see dashed line). Inactivity and obesity together (blue) further increase the risk for developing chronic diseases. Those who exercise chronically (red) have a reduced risk.

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