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Nature 454, 287-288 (17 July 2008) | doi:10.1038/454287a; Published online 16 July 2008
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Signal transduction: Linking nutrients to growth
Vittoria Zinzalla1 & Michael N. Hall1
Abstract
How cells sense nutrients to control growth is largely unknown. One missing link involved in conveying the nutrient signal to the TOR protein, which regulates growth, seems to be the Rag proteins.
In mammalian cells, nutrients (such as amino acids), growth factors and cellular energy together trigger a molecular signalling pathway, mediated by the protein TOR, that controls cell growth. Deregulation of this pathway is implicated in cancer, and TOR inhibition by the anticancer drug rapamycin prevents unruly cell growth.
- Vittoria Zinzalla and Michael N. Hall are in the Biozentrum, University of Basel, CH4056 Basel, Switzerland.
Email: m.hall@unibas.ch
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