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Nature 454, 226-231 (22 June 2008) | doi:10.1038/nature07064;
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IRF4 addiction in multiple myeloma
The transcription factor IRF4 (interferon regulatory factor 4) is required during an immune response for lymphocyte activation and the generation of immunoglobulin-secreting plasma cells. Multiple myeloma, a malignancy of plasma cells, has a complex molecular aetiology with several subgroups defined by gene expression profiling and recurrent chromosomal translocations.
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