Introducing just four specific genes into adult cells causes them to regress to an embryonic stem-cell-like state. At 1%, the efficiency of this process is low, but two tips are at hand on how to make improvements.
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Costello, J. Tips for priming potency. Nature 454, 45–46 (2008). https://doi.org/10.1038/454045a
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DOI: https://doi.org/10.1038/454045a
