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Nature 453, 1239-1243 (18 May 2008) | doi:10.1038/nature07002;
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Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution
Recent data from several organisms indicate that the transcribed portions of genomes are larger and more complex than expected, and that many functional properties of transcripts are based not on coding sequences but on regulatory sequences in untranslated regions or non-coding RNAs. Alternative start and polyadenylation sites and regulation of intron splicing add additional dimensions to the rich transcriptional output.
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