Editor's Summary
26 June 2008
Influenza virus: Mechanism of oseltamivir resistance
The molecular basis for oseltamivir (Tamiflu) resistance in some clinical isolates of the H5N1 influenza virus has been identified as a mutation in the drug's target, viral neuraminidase. However, the enzyme remains susceptible to zanamivir (Relenza), the other neuraminidase inhibitor in general use. This suggests that public health authorities stockpiling antivirals should augment their supplies of oseltamivir with other antiviral drugs to keep open the options for effective drug-combination treatments.
Letter: Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
Patrick J. Collins, Lesley F. Haire, Yi Pu Lin, Junfeng Liu, Rupert J. Russell, Philip A. Walker, John J. Skehel, Stephen R. Martin, Alan J. Hay & Steven J. Gamblin
doi:10.1038/nature06956
First paragraph | Full Text | PDF (595K) | Supplementary information
