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From the following article:

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Stephanie C. Eisenbarth, Oscar R. Colegio, William O'Connor, Fayyaz S. Sutterwala & Richard A. Flavell

Nature 453, 1122-1126(19 June 2008)

doi:10.1038/nature06939

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Aluminium-containing adjuvants stimulate macrophages to produce the pro-inflammatory cytokines IL-1beta and IL-18 in a Nalp3 inflammasome-dependent manner.

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Figure 2

Caspase-1 activation by aluminium adjuvants requires Nalp3 and ASC.

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Figure 3

Alum requires intact endocytic macrophage machinery and causes potassium-gradient-dependent IL-1beta secretion without causing significant cell death.

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Figure 4

Antibody production and TH2-dependent inflammation induced by aluminium adjuvants are decreased in the absence of Nalp3, ASC and caspase-1.

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