Editor's Summary
19 June 2008
T helper 17 cells: Induction and effector functions
The recently discovered TH17 cells, the third subset of effector T helper cells, are the subject of intensive research. They produce the cytokine interleukin-17, coordinate defence against specific pathogens and mediate tissue inflammation. Bettelli et al. review this fast-moving field, focusing on the emergence of the balance between pro-inflammatory TH17 cells and inhibitory Treg cells as key factor in many inflammatory and autoimmune diseases.
Review: Induction and effector functions of TH17 cells
Estelle Bettelli, Thomas Korn, Mohamed Oukka & Vijay K. Kuchroo
doi:10.1038/nature07036
