Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 453, 861-862 (12 June 2008) | doi:10.1038/453861a; Published online 11 June 2008
Open Innovation Challenges
-
Methods to Analyze Consumer Emotions
The Seeker is looking for methods to analyze consumer emotions. This Challenge requires only a writ...
-
Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
- More Challenges
- Powered by:
nature jobs
Manager Medical Writitng
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
Natural Products Chemist
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Biochemistry: Molecular cloaking devices
Thomas Kodadek1
Abstract
Protease enzymes cut other proteins into pieces, but some can be blocked by inhibitors. One such inhibitor binds to the substrate rather than the enzyme, suggesting a new tactic for drug discovery.
Most drug developers try to identify small molecules that bind to a target enzyme with high affinity and specificity. Binding usually occurs at the enzyme's active site; by nestling into this molecular pocket, the drug blocks binding of the enzyme's natural substrate.
- Thomas Kodadek is in the Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9185, USA.
e-mail: Email: thomas.kodadek@utsouthwestern.edu
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
