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Nature 453, 529-533 (7 May 2008) | doi:10.1038/nature06933;
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Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
Cancer stem cells, which share many common properties and regulatory machineries with normal stem cells, have recently been proposed to be responsible for tumorigenesis and to contribute to cancer resistance. The main challenges in cancer biology are to identify cancer stem cells and to define the molecular events required for transforming normal cells to cancer stem cells.
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