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Nature 453, 463-466 (22 May 2008) | doi:10.1038/453463a; Published online 21 May 2008

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Structural biology: Snapshots of DNA repair

Stephen C. Kowalczykowski1

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In recombinational DNA repair, nearly identical sequences in chromosomes are found and swapped. Structures of the RecA–DNA complexes involved provide insight into the mechanism and energetics of this universal process.

Homologous recombination is one of the many processes used by cells to repair damaged DNA and to diversify their genomes. A central step in recombination involves the exchange of DNA strands between identical, or nearly identical, segments of chromosomes.

  1. Stephen C. Kowalczykowski is in the Departments of Microbiology, and of Molecular and Cellular Biology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.
    Email: sckowalczykowski@ucdavis.edu

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