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From the following article:

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

Wei Guo, Joseph L. Lasky, Chun-Ju Chang, Sherly Mosessian, Xiaoman Lewis, Yun Xiao, Jennifer E. Yeh, James Y. Chen, M. Luisa Iruela-Arispe, Marileila Varella-Garcia & Hong Wu

Nature 453, 529-533(22 May 2008)

doi:10.1038/nature06933

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

VEC-Cre-mediated Pten loss leads to MPD and leukaemogenesis.

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Figure 2

Self-renewing LSCs are enriched in the c-KitmidCD3+ compartment.

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Figure 3

beta-Catenin activation in LSCs and its role in leukaemogenesis.

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Figure 4

The recurring translocation T(14;15) involves the Tcra/Tcrd cluster and the c-myc gene and results in aberrant overexpression of c-myc in LSCs and T-ALL blasts.

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