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Nature 453, 314-321 (15 May 2008) | doi:10.1038/nature07039; Published online 14 May 2008
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Professor of Microscopy (W2)
- Friedrich-Schiller-University
- Jena Germany
Head of Formulation R&D
- Syngene International Limited
- Bangalore 560 099 India
Review Article Wound repair and regeneration
Geoffrey C. Gurtner1, Sabine Werner2, Yann Barrandon3,4 & Michael T. Longaker1
Abstract
The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.
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