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Nature 453, 338-344 (15 May 2008) | doi:10.1038/nature07042; Published online 14 May 2008
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Postdoctoral Fellow - Computational Genomics - Team 78 – Ref: 80464
- Wellcome Trust Sanger Institute
- Hinxton, Cambridgeshire CB10 1, UK
Senior Statistical Genetics in High-throughput Sequencing Analysis
- University of Oxford
- Oxford United Kingdom
Review Article A chemical approach to stem-cell biology and regenerative medicine
Yue Xu1, Yan Shi1 & Sheng Ding1
Abstract
An improved understanding of stem-cell and regenerative biology, as well as a better control of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries. Chemical approaches are starting to have an increasingly important role in this young field. Attention has focused on chemical approaches that allow the precise manipulation of cells in vitro to obtain homogeneous cell types for cell-based therapies. Another promising approach is the development of conventional chemical and biological therapeutics to stimulate endogenous cells to regenerate. Such therapeutics can act on target cells or their niches in vivo to promote cell survival, proliferation, differentiation, reprogramming and homing.
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