Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 453, 330-337 (15 May 2008) | doi:10.1038/nature07041; Published online 14 May 2008
Open Innovation Challenges
-
Methods to Analyze Consumer Emotions
The Seeker is looking for methods to analyze consumer emotions. This Challenge requires only a writ...
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Professor of Microscopy (W2)
- Friedrich-Schiller-University
- Jena Germany
Head of Formulation R&D
- Syngene International Limited
- Bangalore 560 099 India
Review Article Tolerance strategies for stem-cell-based therapies
Ann P. Chidgey1, Daniel Layton1, Alan Trounson1,2 & Richard L. Boyd1
Abstract
There is much interest in using embryonic stem cells to regenerate tissues and organs. For this approach to succeed, these stem cells or their derivatives must engraft in patients over the long term. Unless a cell transplant is derived from the patient's own cells, however, the cells will be targeted for rejection by the immune system. Although standard methods for suppressing the immune system achieve some success, rejection of the transplant is inevitable. Emerging approaches to address this issue include 're-educating' the immune system to induce tolerance to foreign cells and reducing the immune targeting of the transplant by administering 'self stem cells' instead of foreign cells, but each of these approaches has associated challenges.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Stemming the tide of rejectionNature Medicine News and Views (01 Feb 2002)
BMT beats autoimmune diseaseNature Medicine News and Views (01 Feb 1998)
Research highlightsNature Biotechnology News and Views (01 Jan 2008)
See all 6 matches for News And Views