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Nature 453, xiv (15 May 2008) | doi:10.1038/7193xivb; Published online 14 May 2008
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Abstractions
The 'progress zone' model of limb development posits that the embryonic cells that become limbs are specified in a progressive manner: first, the upper part; then the middle; and last, hand or foot. Despite there being no direct evidence for this, the model remained unquestioned for more than 25 years.
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