Abstract

Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pathways that lead to disease, as well as targets for therapy.

1. Cardiovascular Research Center, Massachusetts General Hospital, Simches Research Center, 185 Cambridge Street, Boston, Massachusetts 02114, USA.
2. Department of Stem Cell and Regenerative Biology, Harvard University, 42 Church Street, Cambridge, Massachusetts 02138, USA.

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