Figures and Tables : Kemp elimination catalysts by computational enzyme design : Nature

From the following article:

Kemp elimination catalysts by computational enzyme design

Daniela Röthlisberger, Olga Khersonsky, Andrew M. Wollacott, Lin Jiang, Jason DeChancie, Jamie Betker, Jasmine L. Gallaher, Eric A. Althoff, Alexandre Zanghellini, Orly Dym, Shira Albeck, Kendall N. Houk, Dan S. Tawfik & David Baker

Nature 453, 190-195(8 May 2008)

doi:10.1038/nature06879

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Figure 1

Reaction scheme and catalytic motifs used in design.

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Figure 2

Kinetic characterization of designed catalysts.

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Figure 3

Computational design models of the two most active catalysts.

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Figure 4

Comparison of the designed model of KE07 and the crystal structure.

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Table 1

Kinetic parameters of designed enzymes

Full size table and legend

Table 2

Kinetic parameters of KE07 variants

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