TABLE 1
From the following article:
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors
Omobolaji O. Akala, In-Kyung Park, Dalong Qian, Michael Pihalja, Michael W. Becker & Michael F. Clarke
Nature 453, 228-232(8 May 2008)
doi:10.1038/nature06869
Table 1. Frequency of long-term reconstituting cells determined by limiting dilution analysis.
| Genotype | One long-term reconstituting cell in: | Range | Frequency (%) |
|---|---|---|---|
Using the limiting dilution analysis from Supplementary Table 2, the frequency of long-term reconstituting cells was calculated according to Poisson statistics using L-Calc software. | |||
*p16Ink4a-/-p19Arf-/-Trp53-/- bone marrow showed a 10-fold increase in the frequency of cells capable of long-term reconstitution when measured 20 weeks after transplantation compared to wild-type cells (two-tailed t-test; P < 0.0005). The other mutant bone marrow did not show a marked difference in the frequency of long-term reconstituting cells. | |||
| Wild type | 92,049 | 70,278–120,564 | 0.0011 |
| p19Arf-/- | 55,072 | 43,857–69,154 | 0.0018 |
| Trp53-/- | 50,317 | 35,056–72,222 | 0.0020 |
| p16Ink4a-/-p19Arf-/- | 53,002 | 41,344–67,948 | 0.0019 |
| p16Ink4a-/-p19Arf-/-Trp53-/- | 7,657 | 5,221–11,230 | 0.0131* |