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Nature 453, 110-114 (13 April 2008) | doi:10.1038/nature06866;
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BCR|[ndash]|ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR–ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leukaemia samples from 304 individuals with ALL, including 43 BCR–ABL1 B-progenitor ALLs and 23 CML cases.
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