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Editorials

California against cronyism p1

The scale of funds set to be spent by the state on stem-cell research necessitates strong governance.

doi:10.1038/453001a


A research menu p1

More spending on agricultural science is needed to help resolve the world's food crisis.

doi:10.1038/453001b


A place for everything p2

More researchers must record the latitude and longitude of their data.

doi:10.1038/453002a


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Research Highlights

Cell biology: Casting anchor p4

doi:10.1038/453004a


Neurobiology: Pecking order p4

doi:10.1038/453004b


Human biology: Boy appétit p4

doi:10.1038/453004c


Chemical biology: Dope hope p4

doi:10.1038/453004d


Astronomy: Galactic beginnings p4

doi:10.1038/453004e


Animal behaviour: A reassuring tune p4

doi:10.1038/453004f


Molecular physics: Slicing the ice p5

doi:10.1038/453005a


Virology: Rubbish imitation p5

doi:10.1038/453005b


Atmospheric science: Jetting away p5

doi:10.1038/453005c


Neuroscience: Algal vision p5

doi:10.1038/453005d


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Journal Club

Journal club p5

Kristi Anseth

doi:10.1038/453005e


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News

Doctors accused of doing illegal stem-cell trials p6

Patients in Austria may have been misled.

Alison Abbott

doi:10.1038/453006a


US ocean-research projects in dire economic straits p7

Multiple marine projects under threat from cash squeeze.

Rex Dalton

doi:10.1038/453007a


Food crisis spurs research spending p8

Agricultural research comes in from the cold.

Declan Butler

doi:10.1038/453008a


Genetics bill cruises through Senate p9

Unanimous vote welcomed by personal genomics companies.

Meredith Wadman

doi:10.1038/453009a


Snapshot: Rodent round-up p9

It's been a good week for rat-catchers.

doi:10.1038/453009b


If you go down to the woods today ... p11

Eric Hand

doi:10.1038/453011a


Sidelines p12

Scribbles on the margins of science.

doi:10.1038/453012a


Programs promise to end PDF paper-chase p12

Software makes article control a virtual reality.

Rachel Courtland

doi:10.1038/453012b


Sediment cores reveal Antarctica's warmer past p13

Quirin Schiermeier

doi:10.1038/453013a


International consortium to tackle cancer genomes p15

doi:10.1038/453015a


A lift for Europe's satellites p15

doi:10.1038/453015b


Warming Antarctic waters begin to cool p15

doi:10.1038/453015c


UK government slammed for underfunding research p15

doi:10.1038/453015d


Creationists fail in bid to offer 'science' degrees p15

doi:10.1038/453015e


Artist cleared over possession of bacteria p15

doi:10.1038/453015f


Correction p15

doi:10.1038/453015g


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Column

Party of One

Demonstrably wrong p16

Public–private demonstration projects are a good way to test technology in the field. But the driving force is often more political than scientific, argues David Goldston.

David Goldston

doi:10.1038/453016a


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News Features

Stem cells: The 3-billion-dollar question p18

Can a state do what a country cannot, and transform the way stem-cell research is funded? Erika Check Hayden reports on the California Institute for Regenerative Medicine.

doi:10.1038/453018a


Physics: Quantum all the way p22

How does our classical world emerge from the counterintuitive principles of quantum theory? Can we even be sure that the world doesn't 'go quantum' when no one is watching? Philip Ball talks to the theorists and experimentalists trying to find out.

doi:10.1038/453022a


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Correspondence

Biopiracy rules hinder conservation efforts p26

Valentí Rull & Teresa Vegas-Vilarrúbia

doi:10.1038/453026a


Biopiracy: conservationists have to rebuild lost trust p26

Mariana M. Vale, Maria Alice Alves & Stuart L. Pimm

doi:10.1038/453026b


Spain should implement a model that's known to work p26

Rodrigo J. Carbajo, José Luis Neira & Rosa Farràs

doi:10.1038/453026c


Spain: leading role of scientists is heartening p27

Pere Puigdomènech

doi:10.1038/453027a


Darwin–Wallace principle of natural selection p27

U. Kutschera

doi:10.1038/453027b


The status of science in Muslim nations p27

K. Razi Naqvi

doi:10.1038/453027c


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Commentaries

Making the grade p28

International testing that is used to predict the grim future of US science and technology is being vastly misinterpreted, say Hal Salzman and Lindsay Lowell.

doi:10.1038/453028a

See also: Editor's summary


Science teaching must evolve p31

Evolutionary theory, study and knowledge moved on dramatically in the latter half of the twentieth century, but school teaching, curricula and teacher training are still in the primeval soup era, says Andrew Moore.

doi:10.1038/453031a

See also: Editor's summary


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Books and Arts

Mix and mash-up p33

An experimental musician explores how technology has transformed our cut-and-paste culture.

Marc Weidenbaum reviews Sound Unbound: Sampling Digital Music and Culture

doi:10.1038/453033a


Exemplary epidemiology p34

Mark Woolhouse reviews Modeling Infectious Diseases in Humans and Animals by Matt J. Keeling & Pejman Rohani

doi:10.1038/453034a


Exhibition: Measure for measure p35

John D. Barrow reviews Beyond Measure: Conversations Across Art and Science

doi:10.1038/453035a


Exhibition: Changing expressions p36

Laura Spinney reviews Lovis Corinth (1858–1925): Between Impressionism and Expressionism

doi:10.1038/453036a


Exhibition: Etching the artist's mind p36

Colin Martin reviews Scribing the Soul

doi:10.1038/453036b


The Impressionists' bible p37

Ogden Rood's textbook explaining the science of optics and colour mixing triggered an unexpectedly vivid response from the radical artists of the 1880s.

Martin Kemp

doi:10.1038/453037a


In retrospect: When business became biology's plague p38

A 1920s best-seller about risky campus capitalism and early phage therapy still resonates today.

Thomas Häusler reviews Arrowsmith by Sinclair Lewis

doi:10.1038/453038a


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Essay

Lifting the fog from the north p39

A purist approach to wavefunctions can resolve some of quantum theory's infamous murkiness.

Maximilian Schlosshauer

doi:10.1038/453039a

See also: Editor's summary


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News and Views

Neuroscience: Hidden female talent p41

A male fruitfly serenades his female with a courtship song produced by vibrating one wing. The female also has the neuronal circuitry to generate a song of her own, but her brain tells her not to.

Jai Y. Yu & Barry J. Dickson

doi:10.1038/453041a


Electronics: The fourth element p42

Almost four decades since its existence was first proposed, a fourth basic circuit element joins the canonical three. The 'memristor' might herald a step-change in the march towards ever more powerful circuitry.

James M. Tour & Tao He

doi:10.1038/453042a

See also: Editor's summary


Climate change: Natural ups and downs p43

The effects of global warming over the coming decades will be modified by shorter-term climate variability. Finding ways to incorporate these variations will give us a better grip on what kind of climate change to expect.

Richard Wood

doi:10.1038/453043a

See also: Editor's summary


Quantum physics: The squeeze goes on p45

After 20 years of hard labour, squeezed states — light and matter whose quantum fluctuations have been arduously suppressed below standard levels of quantum noise — are coming of age and are ripe for application.

Eugene S. Polzik

doi:10.1038/453045a


Immunology: T cells hang in the balance p46

Equally important as the immune system's function in fighting invaders is its ability to tolerate self. But environmental toxins could shift the equilibrium between these activities one way or the other.

Emily A. Stevens & Christopher A. Bradfield

doi:10.1038/453046a

See also: Editor's summary


Networks: Teasing out the missing links p47

Focusing on the hierarchical structure inherent in social and biological networks might provide a smart way to find missing connections that are not revealed in the raw data — which could be useful in a range of contexts.

Sid Redner

doi:10.1038/453047a

See also: Editor's summary


Astrophysics: Rays from the dark p48

The origin of the cosmic rays that bombard Earth has troubled physicists for nigh on a century. Supernova remnants are a favoured source — but we should keep our minds open to alternatives.

Rainer Plaga

doi:10.1038/453048a


Obituary: John Wheeler (1911–2008) p50

Theoretical physicist, inspired and inspiring teacher.

P. James E. Peebles & William G. Unruh

doi:10.1038/453050a

See also: Editor's summary


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Articles

Rapid leukocyte migration by integrin-independent flowing and squeezing p51

Tim Lämmermann, Bernhard L. Bader, Susan J. Monkley, Tim Worbs, Roland Wedlich-Söldner, Karin Hirsch, Markus Keller, Reinhold Förster, David R. Critchley, Reinhard Fässler & Michael Sixt

doi:10.1038/nature06887

See also: Editor's summary


Mapping and sequencing of structural variation from eight human genomes p56

Jeffrey M. Kidd, Gregory M. Cooper, William F. Donahue, Hillary S. Hayden, Nick Sampas, Tina Graves, Nancy Hansen, Brian Teague, Can Alkan, Francesca Antonacci, Eric Haugen, Troy Zerr, N. Alice Yamada, Peter Tsang, Tera L. Newman, Eray Tüzün, Ze Cheng, Heather M. Ebling, Nadeem Tusneem, Robert David, Will Gillett, Karen A. Phelps, Molly Weaver, David Saranga, Adrianne Brand, Wei Tao, Erik Gustafson, Kevin McKernan, Lin Chen, Maika Malig, Joshua D. Smith, Joshua M. Korn, Steven A. McCarroll, David A. Altshuler, Daniel A. Peiffer, Michael Dorschner, John Stamatoyannopoulos, David Schwartz, Deborah A. Nickerson, James C. Mullikin, Richard K. Wilson, Laurakay Bruhn, Maynard V. Olson, Rajinder Kaul, Douglas R. Smith & Evan E. Eichler

doi:10.1038/nature06862

See also: Editor's summary


Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor p65

Francisco J. Quintana, Alexandre S. Basso, Antonio H. Iglesias, Thomas Korn, Mauricio F. Farez, Estelle Bettelli, Mario Caccamo, Mohamed Oukka & Howard L. Weiner

doi:10.1038/nature06880

See also: Editor's summary | News and Views by Stevens & Bradfield


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Letters

The sculpting of Jupiter's gossamer rings by its shadow p72

Douglas P. Hamilton & Harald Krüger

doi:10.1038/nature06886

See also: Editor's summary


Phase-slip-induced dissipation in an atomic Bose–Hubbard system p76

D. McKay, M. White, M. Pasienski & B. DeMarco

doi:10.1038/nature06920


The missing memristor found p80

Dmitri B. Strukov, Gregory S. Snider, Duncan R. Stewart & R. Stanley Williams

doi:10.1038/nature06932

See also: Editor's summary | News and Views by Tour & He


Advancing decadal-scale climate prediction in the North Atlantic sector p84

N. S. Keenlyside, M. Latif, J. Jungclaus, L. Kornblueh & E. Roeckner

doi:10.1038/nature06921

See also: Editor's summary | News and Views by Wood


Origin of a 'Southern Hemisphere' geochemical signature in the Arctic upper mantle p89

Steven L. Goldstein, Gad Soffer, Charles H. Langmuir, Kerstin A. Lehnert, David W. Graham & Peter J. Michael

doi:10.1038/nature06919


Hydatellaceae are water lilies with gymnospermous tendencies p94

William E. Friedman

doi:10.1038/nature06733

See also: Editor's summary


Hierarchical structure and the prediction of missing links in networks p98

Aaron Clauset, Cristopher Moore & M. E. J. Newman

doi:10.1038/nature06830

See also: Editor's summary | News and Views by Redner


Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision p102

Ali D. Güler, Jennifer L. Ecker, Gurprit S. Lall, Shafiqul Haq, Cara M. Altimus, Hsi-Wen Liao, Alun R. Barnard, Hugh Cahill, Tudor C. Badea, Haiqing Zhao, Mark W. Hankins, David M. Berson, Robert J. Lucas, King-Wai Yau & Samer Hattar

doi:10.1038/nature06829

See also: Editor's summary


The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins p106

Marc Veldhoen, Keiji Hirota, Astrid M. Westendorf, Jan Buer, Laure Dumoutier, Jean-Christophe Renauld & Brigitta Stockinger

doi:10.1038/nature06881

See also: Editor's summary | News and Views by Stevens & Bradfield


BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros p110

Charles G. Mullighan, Christopher B. Miller, Ina Radtke, Letha A. Phillips, James Dalton, Jing Ma, Deborah White, Timothy P. Hughes, Michelle M. Le Beau, Ching-Hon Pui, Mary V. Relling, Sheila A. Shurtleff & James R. Downing

doi:10.1038/nature06866

See also: Editor's summary


Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions p115

Stavroula Mili, Konstadinos Moissoglu & Ian G. Macara

doi:10.1038/nature06888

See also: Editor's summary


Life without RNase P p120

Lennart Randau, Imke Schröder & Dieter Söll

doi:10.1038/nature06833

See also: Editor's summary


Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS p124

Raz Zarivach, Wanyin Deng, Marija Vuckovic, Heather B. Felise, Hai V. Nguyen, Samuel I. Miller, B. Brett Finlay & Natalie C. J. Strynadka

doi:10.1038/nature06832


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Corrigendum

Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila p128

Cathy Haag-Liautard, Mark Dorris, Xulio Maside, Steven Macaskill, Daniel L. Halligan, David Houle, Brian Charlesworth & Peter D. Keightley

doi:10.1038/nature06946


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Naturejobs

Prospect

Prospects p129

US National Postdoctoral Association campaigns for stipend boost.

Gene Russo

doi:10.1038/nj7191-129a


Career View

Eaton E. Lattman, chief executive and executive director of the Hauptman-Woodward Medical Research Institute, Buffalo, New York p130

Crystallographer takes over at Buffalo's Hauptman-Woodward Medical Research Institute.

Virginia Gewin

doi:10.1038/nj7191-130a


Crossing borders p130

Training programme links Stockholm and New York.

Paul Smaglik

doi:10.1038/nj7191-130b


Meeting our targets p130

Evaluating the metrics of my own 'success'.

Amanda Goh

doi:10.1038/nj7191-130c


Highlights

Opportunities: The National Institutes of Health

doi:10.1038/nj0206


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Futures

Build your own time machine p132

It's a unique set of experiences.

Igor Teper

doi:10.1038/453132a


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