Why would two distant genes — on separate chromosomes and from different nuclear locations — unite in response to signals for gene expression? They might be seeds for the formation of transcriptional hubs.
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Lonard, D., O'Malley, B. Two worlds merged. Nature 452, 946–947 (2008). https://doi.org/10.1038/452946a
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DOI: https://doi.org/10.1038/452946a