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Editorials

New sources of sex cells p913

Within the next decade or so, it will become possible to derive sperm and eggs from skin cells. The ethical and technical hurdles need to be addressed with the scientific and therapeutic benefits in mind.

doi:10.1038/452913a


The big ome p913

It's time to make the case for proteins.

doi:10.1038/452913b


Superconductors redux p914

Yet another surprise has been uncovered in the complex oxides.

doi:10.1038/452914a


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Research Highlights

Research highlights p916

doi:10.1038/452916a


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Journal Club

Journal club p917

Vijay Kuchroo

doi:10.1038/452917a


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News

Data show extent of sexism in physics p918

Experiment at Fermilab gave women fewer opportunities to present at conferences.

Geoff Brumfiel

doi:10.1038/452918a


Italian group claims to see dark matter — again p918

Gran Sasso detector picks up unusual signal.

Geoff Brumfiel

doi:10.1038/452918b


Swiss 'dignity' law is threat to plant biology p919

Government ethics committee guidelines could halt techniques such as hybridization of roses.

Alison Abbott

doi:10.1038/452919a


Biologists initiate plan to map human proteome p920

Project aims to characterize all human proteins.

Helen Pearson

doi:10.1038/452920a


Buckyballs give flash a boost p921

Eric Hand

doi:10.1038/452921a


Arsenic heats up iron superconductors p922

Eric Hand

doi:10.1038/452922a


Politically correct names given to flu viruses p923

World Health Organization standardizes nomenclature, but experts say GPS sample locations should be given.

Declan Butler

doi:10.1038/452923a


Sidelines p923

Scribbles on the margins of science.

doi:10.1038/452923b


Fake drugs: lessons for the world p924

Dora Akunyili is director-general of Nigeria's National Agency for Food and Drug Administration and Control (NAFDAC). Since her appointment in 2001, she has led a successful crusade against counterfeit pharmaceuticals, which are responsible for millions of deaths worldwide each year. Nature caught up with her last week in Washington DC.

Meredith Wadman

doi:10.1038/452924a


Bubble-fusion engineer sues other scientists p925

doi:10.1038/452925a


US biodefence agency appoints first director p925

doi:10.1038/452925b


Research assessment panel advised to destroy all notes p925

doi:10.1038/452925c


GlaxoSmithKline does deal to develop microRNA drugs p925

doi:10.1038/452925d


UN ruling makes Australia an even bigger country p925

doi:10.1038/452925e


Botanical art gallery opens in London p925

doi:10.1038/452925f


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News Features

Biomedical science: Betting the bank p926

Lyle Palmer has plans for a "ludicrously ambitious" gene–disease research project. Bijal Trivedi reports on the trials at Joondalup.

doi:10.1038/452926a


Atmospheric physics: Heating up the heavens p930

Battling rumours of death beams and mind control, an ionosphere research facility in Alaska finally brings science to the fore. Sharon Weinberger reports.

doi:10.1038/452930a


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Correspondence

Media right to report small value of antidepressants p934

Olavo B. Amaral

doi:10.1038/452934a


Tropical farmers need productive alternatives p934

Thomas Knoke, Bernd Stimm & Michael Weber

doi:10.1038/452934b


Researchers should explain why they use animals p934

doi:10.1038/452934c


Truth about a plant with many names p934

Marko Kreft & Robert Zorec

doi:10.1038/452934d


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Commentary

Europe's research system must change p935

Science funding in the European Union needs to be revised to better serve economic, social and environmental goals, Luke Georghiou argues.

doi:10.1038/452935a

See also: Editor's summary


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Books and Arts

Orange revolution p937

Stories of seventeeth-century scientists and aristocrats show how Dutch ingenuity benefited England.

Harold Cook reviews Going Dutch: How England Plundered Holland's Glory by Lisa Jardine.

doi:10.1038/452937a


Biased brains, messy memories p938

Sandra Aamodt reviews Kluge: The Haphazard Construction of the Human Mind by Gary Marcus and A Portrait of the Brain by Adam Zeman.

doi:10.1038/452938a


Technological twist on taxonomy p939

Kevin Kelly reviews Systematics as Cyberscience: Computers, Change, and Continuity in Science by Christine Hine.

doi:10.1038/452939a


Hidden treasures: the Cajal collection in Madrid p940

The perceptive drawings, paintings, photographs and slides of Spain's neuroanatomy pioneer record a tale of ambition and rivalry, reports Alison Abbott.

doi:10.1038/452940a


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News and Views

Metabolism: Food alert p941

The gut prevents nutrient overload during a meal by promoting satiety and enhancing insulin secretion. New findings show that nutrients in the gut also activate a neural circuit that increases insulin sensitivity.

Joshua P. Thaler & David E. Cummings

doi:10.1038/452941a

See also: Editor's summary


Optics: Light reined in p942

Light always travels at the same speed in a vacuum, no more, no less. But in materials, there's room for manoeuvre: tweak the right material in the right way, and exciting optoelectronic properties result.

Diederik Sybolt Wiersma

doi:10.1038/452942a


50 & 100 Years Ago p943

doi:10.1038/452943a


Neuroscience: Current views on odour receptors p944

Insects possess refined olfactory systems that use specific receptors on their antennae. It emerges that these receptors not only detect odour molecules but, unexpectedly, can also act as ion channels.

Alexander Chesler & Stuart Firestein

doi:10.1038/452944a

See also: Editor's summary


Oceanography: Bottom of the top of the world p945

Tim Lincoln

doi:10.1038/452945a


Astrophysics: Exhaust inspection p945

What do you see if you peer into the exhaust of a jet engine larger than our Solar System? Only astronomers with the largest radio telescopes can see the full picture — and definitive observations are beginning to filter through.

David L. Meier

doi:10.1038/452945b

See also: Editor's summary


Gene transcription: Two worlds merged p946

Why would two distant genes — on separate chromosomes and from different nuclear locations — unite in response to signals for gene expression? They might be seeds for the formation of transcriptional hubs.

David M. Lonard & Bert W. O'Malley

doi:10.1038/452946a


Plant biology: Scent of a rose p947

Sadaf Shadan

doi:10.1038/452947a


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Articles

The genome of the model beetle and pest Tribolium castaneum p949

Tribolium Genome Sequencing Consortium

doi:10.1038/nature06784

See also: Editor's summary


Lateral presynaptic inhibition mediates gain control in an olfactory circuit p956

Shawn R. Olsen & Rachel I. Wilson

doi:10.1038/nature06864

See also: Editor's summary


Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA p961

Cai-Guang Yang, Chengqi Yi, Erica M. Duguid, Christopher T. Sullivan, Xing Jian, Phoebe A. Rice & Chuan He

doi:10.1038/nature06889


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Letters

The inner jet of an active galactic nucleus as revealed by a radio-to-bold gamma-ray outburst p966

Alan P. Marscher, Svetlana G. Jorstad, Francesca D. D'Arcangelo, Paul S. Smith, G. Grant Williams, Valeri M. Larionov, Haruki Oh, Alice R. Olmstead, Margo F. Aller, Hugh D. Aller, Ian M. McHardy, Anne Lähteenmäki, Merja Tornikoski, Esko Valtaoja, Vladimir A. Hagen-Thorn, Eugenia N. Kopatskaya, Walter K. Gear, Gino Tosti, Omar Kurtanidze, Maria Nikolashvili, Lorand Sigua, H. Richard Miller & Wesley T. Ryle

doi:10.1038/nature06895

See also: Editor's summary | News and Views by Meier


A topological Dirac insulator in a quantum spin Hall phase p970

D. Hsieh, D. Qian, L. Wray, Y. Xia, Y. S. Hor, R. J. Cava & M. Z. Hasan

doi:10.1038/nature06843

See also: Editor's summary


Small phonon contribution to the photoemission kink in the copper oxide superconductors p975

Feliciano Giustino, Marvin L. Cohen & Steven G. Louie

doi:10.1038/nature06874


Eocene/Oligocene ocean de-acidification linked to Antarctic glaciation by sea-level fall p979

Agostino Merico, Toby Tyrrell & Paul A. Wilson

doi:10.1038/nature06853

See also: Editor's summary


Hydrous silicate melt at high pressure p983

Mainak Mookherjee, Lars Stixrude & Bijaya Karki

doi:10.1038/nature06918

See also: Editor's summary


Mountain pine beetle and forest carbon feedback to climate change p987

W. A. Kurz, C. C. Dymond, G. Stinson, G. J. Rampley, E. T. Neilson, A. L. Carroll, T. Ebata & L. Safranyik

doi:10.1038/nature06777

See also: Editor's summary


The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus) p991

Ray Ming, Shaobin Hou, Yun Feng, Qingyi Yu, Alexandre Dionne-Laporte, Jimmy H. Saw, Pavel Senin, Wei Wang, Benjamin V. Ly, Kanako L. T. Lewis, Steven L. Salzberg, Lu Feng, Meghan R. Jones, Rachel L. Skelton, Jan E. Murray, Cuixia Chen, Wubin Qian, Junguo Shen, Peng Du, Moriah Eustice, Eric Tong, Haibao Tang, Eric Lyons, Robert E. Paull, Todd P. Michael, Kerr Wall, Danny W. Rice, Henrik Albert, Ming-Li Wang, Yun J. Zhu, Michael Schatz, Niranjan Nagarajan, Ricelle A. Acob, Peizhu Guan, Andrea Blas, Ching Man Wai, Christine M. Ackerman, Yan Ren, Chao Liu, Jianmei Wang, Jianping Wang, Jong-Kuk Na, Eugene V. Shakirov, Brian Haas, Jyothi Thimmapuram, David Nelson, Xiyin Wang, John E. Bowers, Andrea R. Gschwend, Arthur L. Delcher, Ratnesh Singh, Jon Y. Suzuki, Savarni Tripathi, Kabi Neupane, Hairong Wei, Beth Irikura, Maya Paidi, Ning Jiang, Wenli Zhang, Gernot Presting, Aaron Windsor, Rafael Navajas-Pérez, Manuel J. Torres, F. Alex Feltus, Brad Porter, Yingjun Li, A. Max Burroughs, Ming-Cheng Luo, Lei Liu, David A. Christopher, Stephen M. Mount, Paul H. Moore, Tak Sugimura, Jiming Jiang, Mary A. Schuler, Vikki Friedman, Thomas Mitchell-Olds, Dorothy E. Shippen, Claude W. dePamphilis, Jeffrey D. Palmer, Michael Freeling, Andrew H. Paterson, Dennis Gonsalves, Lei Wang & Maqsudul Alam

doi:10.1038/nature06856

See also: Editor's summary


Genetic variation in human NPY expression affects stress response and emotion p997

Zhifeng Zhou, Guanshan Zhu, Ahmad R. Hariri, Mary-Anne Enoch, David Scott, Rajita Sinha, Matti Virkkunen, Deborah C. Mash, Robert H. Lipsky, Xian-Zhang Hu, Colin A. Hodgkinson, Ke Xu, Beata Buzas, Qiaoping Yuan, Pei-Hong Shen, Robert E. Ferrell, Stephen B. Manuck, Sarah M. Brown, Richard L. Hauger, Christian S. Stohler, Jon-Kar Zubieta & David Goldman

doi:10.1038/nature06858

See also: Editor's summary


Insect olfactory receptors are heteromeric ligand-gated ion channels p1002

Koji Sato, Maurizio Pellegrino, Takao Nakagawa, Tatsuro Nakagawa, Leslie B. Vosshall & Kazushige Touhara

doi:10.1038/nature06850

See also: Editor's summary | News and Views by Chesler & Firestein


Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels p1007

Dieter Wicher, Ronny Schäfer, René Bauernfeind, Marcus C. Stensmyr, Regine Heller, Stefan H. Heinemann & Bill S. Hansson

doi:10.1038/nature06861

See also: Editor's summary | News and Views by Chesler & Firestein


Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production p1012

Penny Y. T. Wang, Liora Caspi, Carol K. L. Lam, Madhu Chari, Xiaosong Li, Peter E. Light, Roger Gutierrez-Juarez, Michelle Ang, Gary J. Schwartz & Tony K. T. Lam

doi:10.1038/nature06852

See also: Editor's summary | News and Views by Thaler & Cummings


A deadenylation negative feedback mechanism governs meiotic metaphase arrest p1017

Eulàlia Belloc & Raúl Méndez

doi:10.1038/nature06809


Crystal structure of the lambda repressor and a model for pairwise cooperative operator binding p1022

Steven Stayrook, Peera Jaru-Ampornpan, Jenny Ni, Ann Hochschild & Mitchell Lewis

doi:10.1038/nature06831


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Naturejobs

Prospect

Prospects p1027

Even as science and engineering in China ascends, its graduate students and postdocs often struggle.

Gene Russo

doi:10.1038/nj7190-1027a


Special Report

China's challenge p1028

Young researchers in China face stiff competition as they strive to establish labs or find other scientific careers. Wei Zeng explores what it takes to succeed as a Chinese scientist.

Wei Zeng

doi:10.1038/nj7190-1028a


Career View

Marja Makarow, chief executive, European Science Foundation, Strasbourg, France p1030

New European Science Foundation chief executive brings varied experience.

Jill U. Adams

doi:10.1038/nj7190-1030a


A guiding COMPASS p1030

From a student's struggles, a new mentor programme for minority students blossoms.

Betty Mbom

doi:10.1038/nj7190-1030b


In the name of science p1030

I sacrifice an awful lot in the name of science.

Aliza le Roux

doi:10.1038/nj7190-1030c


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Futures

SETI for profit p1032

A capital idea.

Gregory Benford

doi:10.1038/4521032a


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