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Nature 452, 941-942 (24 April 2008) | doi:10.1038/452941a; Published online 23 April 2008
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Postdoctoral Research in Functional Genomics
- Harvard School of Public Health, computer science, biology, bioinformatics,
- Boston, MA
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Metabolism: Food alert
Joshua P. Thaler1 & David E. Cummings1
Abstract
The gut prevents nutrient overload during a meal by promoting satiety and enhancing insulin secretion. New findings show that nutrients in the gut also activate a neural circuit that increases insulin sensitivity.
Eating is essential to life, yet its episodic nature necessitates physiological adaptations to avoid excesses or deficits in circulating fuels, especially glucose and lipids1. As the first point of contact with ingested food, the gastrointestinal tract is ideally positioned to initiate after-meal adaptations.
- Joshua P. Thaler and David E. Cummings are in the Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center and VA Puget Sound Health Care System, 1660 South Columbian Way, S-111-Endo, University of Washington, Seattle, Washington 98108, USA.
Email: davidec@u.washington.edu
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Upper intestinal lipids trigger a gut?brain?liver axis to regulate glucose productionNature Letters to Editor (24 Apr 2008)
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose productionNature Medicine Article (01 Jun 2003)
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