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Nature 452, x (17 April 2008) | doi:10.1038/7189xa; Published online 16 April 2008

Making the paper: Sakari Kauppinen

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Therapies that target small RNA molecules show promise in animals.

It is only a few years since tiny RNA molecules called microRNAs were found to have roles in disease, but a therapeutic approach that targets one of them is already yielding promising results. Sakari Kauppinen and his colleagues at Santaris Pharma in Hørsholm, Denmark, in collaboration with the Connecticut-based company RxGen and Stanford University in California, have successfully blocked the activity of one type of microRNA in non-human primates.