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Nature 452, 811 (17 April 2008) | doi:10.1038/452811a; Published online 16 April 2008

Open Innovation Challenges

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Vaccine trial provided valuable information

David Baltimore1

  1. California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA

Your Editorials 'Broken promises' and 'Mismanaged measures' (Nature 452, 503 and 504; 2008) seem to be contradictory. In the former, you excoriate the research community for running human efficacy trials for AIDS vaccines, whereas in the latter you complain about the use of surrogate end points.

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