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Editorials

The path to productive partnerships p665

Research funders and institutions do too little to sustain the collaborations that they encourage.

doi:10.1038/452665a


Defining 'natural' p665

Visceral reactions to an act should not distract from the real ethical issues.

doi:10.1038/452665b


Ready or not p666

Transparency and honesty are essential if the genetic-testing industry is to live up to its potential.

doi:10.1038/452666a


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Research Highlights

Research highlights p668

doi:10.1038/452668a


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Journal Club

Journal club p669

Norbert Perrimon

doi:10.1038/452669a


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News

FDA to vet embryonic stem cells' safety p670

US agency holds first public hearings to assess therapies.

Monya Baker

doi:10.1038/452670a


Advanced biofuels face an uncertain future p670

Aggressive US mandate may do more harm than good.

Jeff Tollefson

doi:10.1038/452670b


Chemical weapons agency shifts focus p671

Diplomats ponder the dangers posed by the drug industry.

Daniel Cressey

doi:10.1038/452671a


Sidelines p672

Scribbles on the margins of science.

doi:10.1038/452672a


Gertrude versus Goliath p672

Octogenarian takes on the electronics giants over LED patents.

Geoff Brumfiel

doi:10.1038/452672b


The fraudster returns... p672

Hans Gottinger is back on the scientific scene.

Alison Abbott

doi:10.1038/452672c


Q&A: Bill Foster p673

At the age of 19, Bill Foster started a theatrical lighting company that now provides equipment for rock concerts and Super Bowl shows. A PhD at Harvard led him to Fermilab in Batavia, Illinois, where he built electronics for a quark detector. In an election win last month, he entered Congress as a Democratic representative for Illinois. Eric Hand caught up with him.

Eric Hand

doi:10.1038/452673a


Poll results: look who's doping p674

In January, Nature launched an informal survey into readers' use of cognition-enhancing drugs. Brendan Maher has waded through the results and found large-scale use and a mix of attitudes towards the drugs.

Brendan Maher

doi:10.1038/452674a


Radio sweat gland — 90 GHz p676

The perils of perspiration.

Philip Ball

doi:10.1038/452676a


UK satellite firm acquired by European space giant p677

doi:10.1038/452677a


Brucellosis fears hamper Yellowstone bison plans p677

doi:10.1038/452677b


Tanzania takes steps to save ancient human prints p677

doi:10.1038/452677c


Pfizer fails to gain access to peer-review files p677

doi:10.1038/452677d


Environment agency reopens doors to libraries p677

doi:10.1038/452677e


An insight into amber p677

doi:10.1038/452677f


Correction p677

doi:10.1038/452677g


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News Features

Evolution: Scandal! Sex-starved and still surviving p678

Some creatures have what it takes to survive long dry spells. How they do this may be revealed in their genes, reports Erika Check Hayden.

doi:10.1038/452678a


Collaborations: With all good intentions p682

Collaborations spawn fresh ideas and boost productivity — most of the time. Heidi Ledford examines what happens when a working relationship breaks down, and asks how to avoid it.

doi:10.1038/452682a


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Correspondence

CropLife still committed to assessment's original aims p685

Howard Minigh

doi:10.1038/452685a


Italy must invest more in science and technology p685

Ivano Bertini, Silvio Garattini & Rino Rappuoli

doi:10.1038/452685b


Cleaning up the final phase of the fossil-fuel industry p685

Steve Larter

doi:10.1038/452685c


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Commentary

Collaborations:  Investigating international misconduct p686

The rise in cross-border collaborations is making it more difficult to police misconduct. Christine Boesz and Nigel Lloyd argue for a framework to examine allegations and hold researchers accountable.

doi:10.1038/452686a


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Spring Books

Shaking the foundations of archaeology p689

Did earthquakes trigger the collapse of ancient civilizations?

Andrew Robinson reviews Apocalypse: Earthquakes, Archaeology and the Wrath of God by Amos Nur & Dawn Burgess

doi:10.1038/452689a


New in Paperback p689

doi:10.1038/452689b


Brave new bioethics p690

Eugenie Scott reviews Life As It Is: Biology for the Public Sphere by William F. Loomis

doi:10.1038/452690a


Engines of life p691

Tim Lenton reviews Energy in Nature and Society by Vaclav Smil

doi:10.1038/452691a


Biology from the bottom up p692

Steven Benner reviews What Is Life? Investigating the Nature of Life in the Age of Synthetic Biology by Ed Regis

doi:10.1038/452692a


Bottling the nuclear demon p694

Martin van Creveld reviews Why Nuclear Disarmament Matters by Hans Blix and On Nuclear Terrorism by Michael Levi

doi:10.1038/452694a


How music speaks to us p695

David Poeppel & Elika Bergelson review Music, Language, and the Brain by Aniruddh D. Patel

doi:10.1038/452695a


Catching a ride on sunshine p696

Stuart Clark reviews Solar Sails: A Novel Approach to Interplanetary Travel by Giovanni Vulpetti, Les Johnson & Gregory L. Matloff

doi:10.1038/452696a


Imaging the unseen p697

Felice Frankel reviews Six Stories from the End of Representation: Images in Painting, Photography, Astronomy, Microscopy, Particle Physics, and Quantum Mechanics, 1980–2000 by James Elkins

doi:10.1038/452697a


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Essay

Rise of the digital machine p699

Genomes and language suggest that biological and social complexity emerge from how information is used, argues Mark Pagel, not from how much of it there is.

Mark Pagel

doi:10.1038/452699a


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News and Views

Atmospheric chemistry: Are plant emissions green? p701

Hydrocarbon emissions from living vegetation are thought to be harmful to the atmosphere. But the latest study suggests that the negative impact of these emissions in pristine environments is less than expected.

Alex Guenther

doi:10.1038/452701a

See also: Editor's summary


Immunology: Blood lines redrawn p702

The generation of blood cells is a complex affair. As the culmination of several years of study by various investigators, the latest research will necessitate revision of textbook accounts of the process.

Thomas Graf

doi:10.1038/452702a

See also: Editor's summary


Materials science: Strong teeth, strong seeds p703

A full account of the relationships between tooth form, structure and function remains out of reach. Viewing teeth from an engineering materials perspective offers a way to help crack the problem.

Peter Ungar

doi:10.1038/452703a


50 & 100 Years Ago p704

doi:10.1038/452704a


Quantum physics: Observations turn up the heat p705

The idea that observers can influence what they observe has a history that stretches back beyond quantum physics. That we can affect how a system heats up and cools down simply by probing it is a new twist.

Kimberly R. Chapin & Marlan O. Scully

doi:10.1038/452705a

See also: Editor's summary


Cell biology: Porter and sorter p706

Clathrin is a protein familiar for its ability to import material into cells. But it also seems to mediate another crucial process — helping newly made proteins to pick the right destination on the cell surface.

Michael G. Roth

doi:10.1038/452706a

See also: Editor's summary


Neurodegeneration: A question of balance p707

When a disease-associated gene is mutated, is the cellular activity of its protein product enhanced or reduced? For at least one neurodegenerative disease, spinocerebellar ataxia 1, the answer seems to be both.

Leslie Michels Thompson

doi:10.1038/452707a

See also: Editor's summary


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News and Views Q&A

Cell biology: SUMO p709

A protein called small ubiquitin-related modifier (SUMO) can be coupled to other proteins to control their function. This SUMOylation has been implicated in the regulation of a host of cellular processes, and is essential for the health, and even the survival, of most organisms.

Erik Meulmeester & Frauke Melchior

doi:10.1038/452709a

See also: Editor's summary


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Articles

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 p713

Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B. Bowman, Ronald Richman, David E. Hill, Harry T. Orr & Huda Y. Zoghbi

doi:10.1038/nature06731

See also: Editor's summary | News and Views by Thompson


Clathrin is a key regulator of basolateral polarity p719

Sylvie Deborde, Emilie Perret, Diego Gravotta, Ami Deora, Susana Salvarezza, Ryan Schreiner & Enrique Rodriguez-Boulan

doi:10.1038/nature06828

See also: Editor's summary | News and Views by Roth


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Letters

Thermodynamic control by frequent quantum measurements p724

Noam Erez, Goren Gordon, Mathias Nest & Gershon Kurizki

doi:10.1038/nature06873

See also: Editor's summary | News and Views by Chapin & Scully


Microscopic theory of the extraordinary optical transmission p728

Haitao Liu & Philippe Lalanne

doi:10.1038/nature06762

See also: Editor's summary


Improper ferroelectricity in perovskite oxide artificial superlattices p732

Eric Bousquet, Matthew Dawber, Nicolas Stucki, Céline Lichtensteiger, Patrick Hermet, Stefano Gariglio, Jean-Marc Triscone & Philippe Ghosez

doi:10.1038/nature06817

See also: Editor's summary


Atmospheric oxidation capacity sustained by a tropical forest p737

J. Lelieveld, T. M. Butler, J. N. Crowley, T. J. Dillon, H. Fischer, L. Ganzeveld, H. Harder, M. G. Lawrence, M. Martinez, D. Taraborrelli & J. Williams

doi:10.1038/nature06870

See also: Editor's summary | News and Views by Guenther


SAR11 marine bacteria require exogenous reduced sulphur for growth p741

H. James Tripp, Joshua B. Kitner, Michael S. Schwalbach, John W. H. Dacey, Larry J. Wilhelm & Stephen J. Giovannoni

doi:10.1038/nature06776

See also: Editor's summary


Broad phylogenomic sampling improves resolution of the animal tree of life p745

Casey W. Dunn, Andreas Hejnol, David Q. Matus, Kevin Pang, William E. Browne, Stephen A. Smith, Elaine Seaver, Greg W. Rouse, Matthias Obst, Gregory D. Edgecombe, Martin V. Sørensen, Steven H. D. Haddock, Andreas Schmidt-Rhaesa, Akiko Okusu, Reinhardt Møbjerg Kristensen, Ward C. Wheeler, Mark Q. Martindale & Gonzalo Giribet

doi:10.1038/nature06614

See also: Editor's summary


Estimating the impact of school closure on influenza transmission from Sentinel data p750

Simon Cauchemez, Alain-Jacques Valleron, Pierre-Yves Boëlle, Antoine Flahault & Neil M. Ferguson

doi:10.1038/nature06732

See also: Editor's summary


A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism p755

Michael Groll, Barbara Schellenberg, André S. Bachmann, Crystal R. Archer, Robert Huber, Tracy K. Powell, Steven Lindow, Markus Kaiser & Robert Dudler

doi:10.1038/nature06782

See also: Editor's summary


Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons p759

Takako Makita, Henry M. Sucov, Cheryl E. Gariepy, Masashi Yanagisawa & David D. Ginty

doi:10.1038/nature06859


The earliest thymic progenitors for T cells possess myeloid lineage potential p764

J. Jeremiah Bell & Avinash Bhandoola

doi:10.1038/nature06840

See also: Editor's summary | News and Views by Graf


Adult T-cell progenitors retain myeloid potential p768

Haruka Wada, Kyoko Masuda, Rumi Satoh, Kiyokazu Kakugawa, Tomokatsu Ikawa, Yoshimoto Katsura & Hiroshi Kawamoto

doi:10.1038/nature06839

See also: Editor's summary | News and Views by Graf


Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome p773

Joshua D. Milner, Jason M. Brenchley, Arian Laurence, Alexandra F. Freeman, Brenna J. Hill, Kevin M. Elias, Yuka Kanno, Christine Spalding, Houda Z. Elloumi, Michelle L. Paulson, Joie Davis, Amy Hsu, Ava I. Asher, John O'Shea, Steven M. Holland, William E. Paul & Daniel C. Douek

doi:10.1038/nature06764


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Naturejobs

Prospect

Prospects p777

The quality of researcher jobs, and not just the quantity, deserves further scrutiny.

Gene Russo

doi:10.1038/nj7188-777a


Career View

Billie Turner, Gilbert F. White chair in environment and society, School of Geographical Sciences, Arizona State University, Tempe, Arizona p778

'Sustainability' pioneer joins Arizona State University.

Virginia Gewin

doi:10.1038/nj7188-778a


Focus on health disparities p778

The NIH adds genetics of health disparities centre to its Bethesda campus.

Paul Smaglik

doi:10.1038/nj7188-778b


The very hungry postdoc p778

Gauging publication risk and reward.

Jon Yearsley

doi:10.1038/nj7188-778c


Highlights

Highlight:Austria

doi:10.1038/nj0203


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Futures

All over, Rover p780

The ghost in the machine.

Neale Morison

doi:10.1038/452780a


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