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Letter

Nature 452, 750-754 (10 April 2008) | doi:10.1038/nature06732; Received 4 December 2007; Accepted 21 January 2008

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Estimating the impact of school closure on influenza transmission from Sentinel data

Simon Cauchemez1, Alain-Jacques Valleron2,3,4, Pierre-Yves Boëlle2,3,4, Antoine Flahault2,3,5 & Neil M. Ferguson1

  1. MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Diseases Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
  2. Université Pierre et Marie Curie—Paris 6, UMR S 707, 27 rue Chaligny, Paris 75012, France
  3. INSERM, UMR S 707, 27 rue Chaligny, Paris 75012, France
  4. AP-HP, Hôpital St Antoine, 27 rue Chaligny, Paris 75012, France
  5. French School of Public Health (EHESP), 1 place du Parvis Notre-Dame, Paris F-75004, France

Correspondence to: Simon Cauchemez1 Correspondence and requests for materials should be addressed to S.C. (Email: s.cauchemez@imperial.ac.uk).

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The threat posed by the highly pathogenic H5N1 influenza virus requires public health authorities to prepare for a human pandemic. Although pre-pandemic vaccines and antiviral drugs might significantly reduce illness rates1, 2, their stockpiling is too expensive to be practical for many countries. Consequently, alternative control strategies, based on non-pharmaceutical interventions, are a potentially attractive policy option. School closure is the measure most often considered. The high social and economic costs of closing schools for months make it an expensive and therefore controversial policy, and the current absence of quantitative data on the role of schools during influenza epidemics means there is little consensus on the probable effectiveness of school closure in reducing the impact of a pandemic. Here, from the joint analysis of surveillance data and holiday timing in France, we quantify the role of schools in influenza epidemics and predict the effect of school closure during a pandemic. We show that holidays lead to a 20–29% reduction in the rate at which influenza is transmitted to children, but that they have no detectable effect on the contact patterns of adults. Holidays prevent 16–18% of seasonal influenza cases (18–21% in children). By extrapolation, we find that prolonged school closure during a pandemic might reduce the cumulative number of cases by 13–17% (18–23% in children) and peak attack rates by up to 39–45% (47–52% in children). The impact of school closure would be reduced if it proved difficult to maintain low contact rates among children for a prolonged period.