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Nature 452, x (10 April 2008) | doi:10.1038/7188xa; Published online 9 April 2008

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Making the paper: David Ginty & Takako Makita

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Blood-vessel proteins guide developing neurons to their targets.

Mammalian nervous systems resemble complex roadmaps, with projections from trillions of cells threading their way within and between tissues and organs. How these projections, or axons, find their way to their destination during development, and whether their fate is predetermined, has been a matter of intense scrutiny.