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News and Views
Nature 452, 706-707 (10 April 2008) | doi:10.1038/452706a; Published online 9 April 2008
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Cell biology: Porter and sorter
Michael G. Roth1
Abstract
Clathrin is a protein familiar for its ability to import material into cells. But it also seems to mediate another crucial process — helping newly made proteins to pick the right destination on the cell surface.
The plasma membrane of differentiated cells, such as sperm, neurons and epithelial cells, is divided into specialized surfaces with distinct protein and lipid compositions. For example, the plasma membrane of epithelial cells is separated by impermeable tight junctions into so-called apical and basolateral domains, which differ considerably in their structure, composition and function.
- Michael G. Roth is in the Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
Email: michael.roth@utsouthwestern.edu
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