Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunology

Blood lines redrawn

Nature volume 452, pages 702–703 (2008)Cite this article

The generation of blood cells is a complex affair. As the culmination of several years of study by various investigators, the latest research will necessitate revision of textbook accounts of the process.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Classic scheme of haematopoiesis with an early bifurcation into lymphoid and myeloid branches.
Figure 2: Revised scheme for thymic T-cell differentiation.

References

  1. Bell, J. J. & Bhandoola, A. Nature 452, 764–767 (2008).

    Article  CAS  ADS  Google Scholar 

  2. Wada, H. et al. Nature 452, 768–772 (2008).

    Article  CAS  ADS  Google Scholar 

  3. Kondo, M., Weissman, I. L. & Akashi, K. Cell 91, 661–672 (1997).

    Article  CAS  Google Scholar 

  4. Akashi, K., Traver, D., Miyamoto, T. & Weissman, I. L. Nature 404, 193–197 (2000).

    Article  CAS  ADS  Google Scholar 

  5. Bhandoola, A., von Boehmer, H., Petrie, H. T. & Zúñiga-Pflücker, J. C. Immunity 26, 678–689 (2007).

    Article  CAS  Google Scholar 

  6. Rothenberg, E. V., Moore, J. E. & Yui, M. A. Nature Rev. Immunol. 8, 9–21 (2008).

    Article  CAS  Google Scholar 

  7. Petrie, H. T. & Zúñiga-Pflücker, J. C. Annu. Rev. Immunol. 25, 649–679 (2007).

    Article  CAS  Google Scholar 

  8. Maillard, I., Fang, T. & Pear, W. S. Annu. Rev. Immunol. 23, 945–974 (2005).

    Article  CAS  Google Scholar 

  9. Ceredig, R. & Rolink, T. Nature Rev. Immunol. 2, 888–897 (2002).

    Article  CAS  Google Scholar 

  10. Laiosa, C. V., Stadtfeld, M. & Graf, T. Annu. Rev. Immunol. 24, 705–738 (2006).

    Article  CAS  Google Scholar 

  11. Katsura, Y. Nature Rev. Immunol. 2, 127–132 (2002).

    Article  CAS  Google Scholar 

  12. Laiosa, C. V., Stadtfeld, M., Xie, H., de Andres-Aguayo, L. & Graf, T. Immunity 25, 731–744 (2006).

    Article  CAS  Google Scholar 

  13. Masuda, K. et al. J. Immunol. 179, 3699–3706 (2007).

    Article  CAS  Google Scholar 

  14. Iwasaki, H. & Akashi, K. Immunity 26, 726–740 (2007).

    Article  CAS  Google Scholar 

  15. Lai, A. Y. & Kondo, M. Proc. Natl Acad. Sci. USA 104, 6311–6316 (2007).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thomas Graf is at the Center for Genomic Regulation, Carrer Dr Aiguader 88, 08003 Barcelona, Spain. thomas.graf@crg.es,

    Thomas Graf

Authors
  1. Thomas Graf
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graf, T. Blood lines redrawn. Nature 452, 702–703 (2008). https://doi.org/10.1038/452702a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/452702a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing