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Nature 452, 580-589 (3 April 2008) | doi:10.1038/nature06917; Published online 2 April 2008
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Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
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Direct Molecular Detection of Proteins and Nucleic Acids
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Senior Researcher in theoretical chemistry / physics
- Italian Institute of Technology
- Lecce, Italy
Research Associate
- University of Glasgow
- Glasgow, UK
Review Article Imaging in the era of molecular oncology
Ralph Weissleder1,2 & Mikael J. Pittet1
Abstract
New technologies for imaging molecules, particularly optical technologies, are increasingly being used to understand the complexity, diversity and in vivo behaviour of cancers. 'Omic' approaches are providing comprehensive 'snapshots' of biological indicators, or biomarkers, of cancer, but imaging can take this information a step further, showing the activity of these markers in vivo and how their location changes over time. Advances in experimental and clinical imaging are likely to improve how cancer is understood at a systems level and, ultimately, should enable doctors not only to locate tumours but also to assess the activity of the biological processes within these tumours and to provide 'on the spot' treatment.
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