Supplementary information

Supplementary Information

The file contains Supplementary Results with additional references, Supplementary Tables 1-7 and Supplementary Figures 1-7 with Legends.
The file contains Supplementary Results on the probes overlapping SNPs, distribution of cis eSNPs as regards the location of probes, detection of trans eQTLs and eQTL hotspots, comparison of expression linkage and association results and finally the additional information regarding genes in the mouse MEMN that have been shown to be causal for metabolic diseases. Tables include a summary of cohort description (Supplementary Table 1), results on the re-sequencing of array probes (Supplementary Table 2), expression trait vs. clinical trait correlations (Supplementary Table 3), heritability and eQTL results (Supplementary Tables 4 and 5), detection of significant trans eQTLs and eQTL hotspots (Supplementary Table 6) and finally the pathway enrichment for the gene sets in the MEMN module (Supplementary Table 7). The figures show chromosomal distribution of eQTLs in IFB in the real data and a simulated dataset (Supplementary Figure 1), distribution of BMI, gene expression vs. BMI correlations and heritability in the IFA cohort (Supplementary Figure 2), the agreement between the linkage and association data (Supplementary Figure 3), distribution of cis eSNPs as regards the location of probes (Supplementary Figure 4), the localization and specificity of the association signal (Supplementary Figure 5), the gene set overlap between the male and female specific MEMN module in humans (Supplementary Figure 6) and finally the comparison between the connectivity structure of the MEMN genes in between the females and males.

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